Neurologian yksikkö
Department of Neurology

Julkaisut 2015
Publications 2015

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1 Arponen O, Muuronen A, Taina M, Sipola P, Hedman M, Jäkälä P, Vanninen R, Pulkki K, Mustonen P. Acute phase IL-10 plasma concentration associates with the high risk sources of cardiogenic stroke. PLoS ONE 2015:10(4):e0120910.
2 Baulac M, de Boer H, Elger C, Glynn M, Kälviäinen R, Little A, Mifsud J, Perucca E, Pitkänen A, Ryvlin P. Epilepsy priorities in Europe: A report of the ILAE-IBE Epilepsy Advocacy Europe Task Force. Epilepsia (NY) 2015:56(11):1687-95.
3 Boccardi M, Bocchetta M, Apostolova LG, Barnes J, ..., Soininen H, ..., Frisoni GB. Delphi definition of the EADC-ADNI Harmonized Protocol for hippocampal segmentation on magnetic resonance. Alzheimers Dement 2015:11:126-138.
4 Bocchetta M, Galluzzi S, Kehoe PG, Aguera E, Bernabei R, Bullock R, Ceccaldi M, Dartigues JF, de Mendonça A, Didic M, Eriksdotter M, Félician O, Frölich L, Gertz HJ, Hallikainen M, Hasselbalch SG, Hausner L, Heuser I, Jessen F, Jones RW, Kurz A, ..., Frisoni GB. The use of biomarkers for the etiologic diagnosis of MCI in Europe: An EADC survey. Alzheimers Dement 2015:11:195-206.
5 Bruun E, Virta LJ, Kälviäinen R, Keränen T. Choice of the first anti-epileptic drug in elderly patients with newly diagnosed epilepsy: A Finnish retrospective study. Seizure 2015:31:27-32.
6 Erkinjuntti T, Remes A, Rinne J, Soininen H, toim. Muistisairaudet. Helsinki: Duodecim, 2015. 696 s.
7 Erkinjuntti T, Remes A, Rinne J, Soininen H. Muistisairaudet: käsitteitä ja termejä. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 18-22. Helsinki: Duodecim, 2015.
8 Ferreira D, Cavallin L, Larsson EM, ..., Soininen H, ..., Westman E, AddNeuroMed consortium and the Alzheimer's Disease Neuroimaging Initative. Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment. J Intern Med 2015:278(3):277-90.
9 Frisoni GB, ..., Frederiksen KS, Liu Y, ..., Soininen H, ..., deLeon M, Pantel J, Ferrari C, Bosco P, Pasqualetti P, Duchesne S, Duvernoy H, Boccardi M. The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity. Alzheimers Dement 2015:11:111-125.
10 Gilmartin JF, Väätäinen S, Törmälehto S, Bell JS, Lönnroos E, Salo L, Hallikainen I, Martikainen J, Koivisto AM. Depressive symptoms are associated with analgesic use in people with Alzheimer's disease: Kuopio ALSOVA study. PLoS ONE 2015:10(2):e0117926.
11 Haanpää RM, Suhonen NM, Hartikainen P, Koivisto AM, Moilanen V, Herukka SK, Hänninen T, Remes AM. The CERAD Neuropsychological Battery in Patients with Frontotemporal Lobar Degeneration. Dement Geriatr Cogn Disord Extra 2015:5(1):147-54.
12 Haapasalo A, Pikkarainen M, Soininen H. Alzheimer's disease: a report from the 7th Kuopio Alzheimer symposium. Neurodegenerat Dis Manage 2015:5(5):379-82.
13 Hall A, Mattila J, Koikkalainen J, Lotjonen J, Wolz R, Scheltens P, Frisoni G, Tsolaki M, Nobili F, Freund-Levi Y, Minthon L, Frölich L, Hampel H, Visser PJ, Soininen H. Predicting progression from cognitive impairment to Alzheimer's disease with the disease state index. Curr Alzheimer Res 2015:12(1):69-79.
14 Hall A, Muñoz-Ruiz M, Mattila J, Koikkalainen J, Tsolaki M, Mecocci P, Kloszewska I, Vellas B, Lovestone S, Visser PJ, Lötjonen J, Soininen H. Generalizability of the disease state index prediction model for identifying patients progressing from mild cognitive impairment to Alzheimer's disease. J Alzheimer Dis 2015:44(1):79-92.
15 Herukka SK, Remes A. Laboratoriotutkimukset. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 355-9. Helsinki: Duodecim, 2015.
16 Herukka SK, Rummukainen J, Ihalainen J, von und zu Fraunberg M, Koivisto AM, Nerg O, Puli LK, Seppälä TT, Zetterberg H, Pyykkö OT, Helisalmi S, Tanila H, Alafuzoff I, Hiltunen M, Rinne J, Soininen H, Jääskeläinen JE, Leinonen V. Amyloid-ß and Tau Dynamics in Human Brain Interstitial Fluid in Patients with Suspected Normal Pressure Hydrocephalus. J Alzheimer Dis 2015:46(1):261-9.
17 Hibar DP, ..., Boks MP, Bralten J, ..., Chen Q, Ching CR, Cuellar-Partida G, den Braber A, Giddaluru S, Goldman AL, Grimm O, Guadalupe T, Hass J, Woldehawariat G, Holmes AJ, Hoogman M, Janowitz D, Jia T, Kim S, ..., Soininen H, ..., Medland SE. Common genetic variants influence human subcortical brain structures. Nature 2015:520(7546):224-9.
18 Hongisto K, Väätäinen S, Martikainen J, Hallikainen I, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. Self-Rated and Caregiver-Rated Quality of Life in Alzheimer Disease with a Focus on Evolving Patient Ability to Respond to Questionnaires: 5-Year Prospective ALSOVA Cohort Study. Am J Geriatr Psychiatry 2015:23(12):1280-9.
19 Huttunen J, Kurki MI, von Und Zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen JE, Kälviäinen R, Immonen A. Epilepsy after aneurysmal subarachnoid hemorrhage: A population-based, long-term follow-up study. Neurology 2015:84(22):2229-37.
20 Hyppönen J, Äikiä M, Joensuu T, Julkunen P, Danner N, Koskenkorva P, Vanninen R, Lehesjoki AE, Mervaala E, Kälviäinen R. Refining the phenotype of unverricht-lundborg disease (EPM1) : a population-wide Finnish study. Neurology 2015:84(15):1529-36.
21 Håkansson K, Soininen H, Winblad B, Kivipelto M. Feelings of Hopelessness in Midlife and Cognitive Health in Later Life: A Prospective Population-Based Cohort Study. PLoS ONE 2015:10(10):e0140261.
22 Junkkari A, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Health-related quality of life in patients with idiopathic normal pressure hydrocephalus. Eur J Neurol 2015:22(10):1391-9.
23 Kaarniranta K, Machalinska A, Veréb Z, Salminen A, Petrovski G, Kauppinen A. Estrogen Signalling in the Pathogenesis of Age-Related Macular Degeneration. Curr Eye Res 2015:40(2):226-33.
24 Kaarre O, Heikkinen N, Vanninen M, Tolmunen T, Äikiä M, Hänninen T, Kivimäki P, Laukkanen E. Long-term alcohol use in adolescence and neurocognition: a preliminary study. Psychiatr Fenn 2015:46:85-102.
25 Kantanen AM, Reinikainen M, Parviainen I, Ruokonen E, Ala-Peijari M, Bäcklund T, Koskenkari J, Laitio R, Kälviäinen R. Incidence and mortality of super-refractory status epilepticus in adults. Epilepsy Behav 2015:49:131-4.
26 Keränen T, Virta L, Kälviäinen R. Valproaatin käytön rajoituksia tarkennetaan raskaudenaikaisten riskien takia. Suomen Lääkärilehti 2015:70(9):572-575.
27 Khan W, Westman E, Jones N, Wahlund LO, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Lovestone S, Muehlboeck JS, Simmons A, AddNeuroMed consortium and for the Alzheimer's Disease Neuroimaging Initiative. Automated Hippocampal Subfield Measures as Predictors of Conversion from Mild Cognitive Impairment to Alzheimer's Disease in Two Independent Cohorts. Brain Topogr 2015:28(5):746-59.
28 Khondoker M, Newhouse S, Westman E, Muehlboeck JS, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Dobson R, Simmons A. Linking Genetics of Brain Changes to Alzheimer's Disease: Sparse Whole Genome Association Scan of Regional MRI Volumes in the ADNI and AddNeuroMed Cohorts. J Alzheimer Dis 2015:45(3):851-864.
29 Kiddle SJ, Steves CJ, Mehta M, ..., Soininen H, ..., Dobson RJ. Plasma protein biomarkers of Alzheimer's disease endophenotypes in asymptomatic older twins: early cognitive decline and regional brain volumes. Transl Psychiatry 2015:5:e584.
30 Kimiskidis VK, Koutlis C, Tsimpiris A, Kälviäinen R, Ryvlin P, Kugiumtzis D. Transcranial Magnetic Stimulation Combined with EEG Reveals Covert States of Elevated Excitability in the Human Epileptic Brain. Int J Neural Syst 2015:25(5):1550018.
31 Kivekäs E, Kinnunen UM, Haatainen K, Kälviäinen R, Saranto K. Trigger Development for the Improvement of Neurological Patient Care. In: Indra Neil Sarkar, Andrew Georgiou, Paulo Mazzoncini de Azevedo Marques, eds. MEDINFO 2015 : eHealth-enabled Health, p. 1116. Amsterdam: IOS Press, 2015. Studies in Health Technology and Informatics. Vol. 216.
32 Kojoukhova M, Koivisto AM, Korhonen R, Remes AM, Vanninen R, Soininen H, Jääskeläinen JE, Sutela A, Leinonen V. Feasibility of radiological markers in idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien) 2015:157(10):1709-19.
33 Korhonen M, Muuronen A, Arponen O, Mustonen P, Hedman M, Jäkälä P, Vanninen R, Taina M. Left atrial appendage morphology in patients with suspected cardiogenic stroke without known atrial fibrillation. PLoS ONE 2015:10(3):e0118822.
34 Kälviäinen R. Intranasal therapies for acute seizures. Epilepsy Behav 2015:49:303-6.
35 Kälviäinen R. Progressive Myoclonus Epilepsies. Semin Neurol 2015:35(3):293-9.
36 Kälviäinen R. Tiagabine. In: Shorvon Simon D, Perucca Emilio, Engel Jerome Jr., eds. Treatment of epilepsy, 4th edition, p. 633-641. Wiley-Blackwell, 2015.
37 Kämäläinen A, Herukka SK, Hartikainen P, Helisalmi S, Moilanen V, Knuuttila A, Jansson L, Tienari PJ, Remes AM. Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Patients with Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis with the C9ORF72 Repeat Expansion. Dement Geriatr Cogn Disord 2015:39(5-6):287-93.
38 Könönen M, Danner N, Koskenkorva P, Kälviäinen R, Hyppönen J, Mervaala E, Karjalainen P, Vanninen R, Niskanen E. Reduced cortical activation in inferior frontal junction in Unverricht-Lundborg disease (EPM1) - A motor fMRI study. Epilepsy Res 2015:111:78-84.
39 Könönen M, Tamsi N, Säisänen L, Kemppainen S, Määttä S, Julkunen P, Jutila L, Äikiä M, Kälviäinen R, Niskanen E, Vanninen R, Karjalainen P, Mervaala E. Non-invasive mapping of bilateral motor speech areas using navigated transcranial magnetic stimulation and functional magnetic resonance imaging. J Neurosci Methods 2015:248:32-40.
40 Laiterä T, Kurki MI, Pursiheimo JP, Zetterberg H, Helisalmi S, Rauramaa T, Alafuzoff I, Remes AM, Soininen H, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. The Expression of Transthyretin and Amyloid-ß Protein Precursor is Altered in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. J Alzheimer Dis 2015:48(4):959-68.
41 Leinonen V, Koivisto A. Normaalipaineinen hydrokefalia. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 187-193. Helsinki: Duodecim, 2015.
42 Leitão MJ, Baldeiras I, Herukka SK, Pikkarainen M, Leinonen V, Simonsen AH, Perret-Liaudet A, Fourier A, Quadrio I, Veiga PM, de OLIVEIRA CR. Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-AD Biomarkers. Front Neurol 2015:6:153.
43 Lleó A, Cavedo E, Parnetti L, Vanderstichele H, Herukka SK, Andreasen N, Ghidoni R, Lewczuk P, Jeromin A, Winblad B, Tsolaki M, Mroczko B, Visser PJ, Santana I, Svenningsson P, Blennow K, Aarsland D, Molinuevo JL, Zetterberg H, Mollenhauer B. Cerebrospinal fluid biomarkers in trials for Alzheimer and Parkinson diseases. Nat Rev Neurol 2015:11(1):41-55.
44 Martiskainen H, Helisalmi S, Viswanathan J, Kurki M, Hall A, Herukka SK, Sarajärvi T, Natunen T, Kurkinen KMA, Huovinen J, Mäkinen P, Laitinen M, Koivisto AM, Mattila KM, Lehtimäki T, Remes AM, Leinonen V, Haapasalo A, Soininen H, Hiltunen M. Effects of Alzheimer's disease-associated risk Loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach. J Alzheimer Dis 2015:43(2):565-73.
45 Martiskainen H, Viswanathan J, Nykänen NP, Kurki M, Helisalmi S, Natunen T, Sarajärvi T, Kurkinen KM, Pursiheimo JP, Rauramaa T, Alafuzoff I, Jääskeläinen JE, Leinonen V, Soininen H, Haapasalo A, Huttunen HJ, Hiltunen M. Transcriptomics and mechanistic elucidation of Alzheimer's disease risk genes in the brain and in vitro models. Neurobiol Aging 2015:36(2):1221.e15-28.
46 Marttinen M, Kurkinen KM, Soininen H, Haapasalo A, Hiltunen M. Synaptic dysfunction and septin protein family members in neurodegenerative diseases. Mol Neurodegener 2015:10:16.
47 Menni C, Kiddle SJ, Mangino M, Viñuela A, Psatha M, Steves C, Sattlecker M, Buil A, Newhouse S, Nelson S, Williams S, Voyle N, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Spector TD, Dobson R, Valdes AM. Circulating Proteomic Signatures of Chronological Age. J Gerontol A Biol Sci Med Sci 2015:70(7):809-16.
48 Miettinen PS, Jauhiainen AM, Tarkka IM, Pihlajamäki M, Gröhn H, Niskanen E, Hänninen T, Vanninen R, Soininen H. Long-Term Response to Cholinesterase Inhibitor Treatment Is Related to Functional MRI Response in Alzheimer's Disease. Dement Geriatr Cogn Disord 2015:40(5-6):243-255.
49 Muraja-Murro A, Mervaala E, Westeren-Punnonen S, Lepola P, Töyräs J, Myllymaa S, Julkunen P, Kantanen AM, Kälviäinen R, Myllymaa K. Forehead EEG electrode set versus full-head scalp EEG in 100 patients with altered mental state. Epilepsy Behav 2015(49):245-9.
50 Muuronen AT, Taina M, Hedman M, Marttila J, Kuusisto J, Onatsu J, Vanninen R, Jäkälä P, Sipola P, Mustonen P. Increased visceral adipose tissue as a potential risk factor in patients with embolic stroke of undetermined source (ESUS). PLoS ONE 2015:10(3):e0120598.
51 Männikkö R, Komulainen P, Schwab U, Heikkilä HM, Savonen K, Hassinen M, Hänninen T, Kivipelto M, Rauramaa R. The Nordic diet and cognition--The DR's EXTRA Study. Br J Nutr 2015:114(2):231-9.
52 Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015:385(9984):2255-2263.
53 Nho K, Kim S, Risacher SL, ..., Soininen H, ..., Ghetti B, Indiana Memory and Aging Study, Saykin AJ, Alzheimer's Disease Neuroimaging Initative. Protective variant for hippocampal atrophy identified by whole exome sequencing. Ann Neurol 2015:77(3):547-552.
54 Proitsi P, Kim M, Whiley L, Pritchard M, Leung R, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Sham P, Lovestone S, Powell JF, Dobson RJB, Legido-Quigley C. Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Transl Psychiatry 2015:5:e494.
55 Ramanan VK, Nho K, Shen L, ..., Soininen H, ..., Saykin AJ. FASTKD2 is associated with memory and hippocampal structure in older adults. Mol Psychiatry 2015:20(10):1197-204.
56 Reijula E, Halkoaho A, Pietilä AM, Selander T, Kälviäinen R, Keränen T. Therapeutic misconception correlates with willingness to participate in clinical drug trials among patients with epilepsy; need for better counseling. Epilepsy Behav 2015:48:29-34.
57 Salminen A, Haapasalo A, Kauppinen A, Kaarniranta K, Soininen H, Hiltunen M. Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Prog Neurobiol 2015:131:1-20.
58 Sarajärvi T, Marttinen M, Natunen T, Kauppinen T, Mäkinen P, Helisalmi S, Laitinen M, Rauramaa T, Leinonen V, Petäjä-Repo U, Soininen H, Haapasalo A, Hiltunen M. Genetic Variation in d-Opioid Receptor Associates with Increased ß- and ?-Secretase Activity in the Late Stages of Alzheimer's Disease. J Alzheimer Dis 2015:48(2):507-16.
59 Shireen S, Calov E, Fokkens J, Ngandu T, Soininen H, Tuomilehto J, Kivipelto M. The CAIDE Dementia Risk Score App: The development of an evidence-based mobile application to predict the risk of dementia . Alzheimers Dement 2015:1(3):328-333.
60 Soininen H, Hänninen T. Muistioireiden taudinmääritys. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 81-89. Helsinki: Duodecim, 2015.
61 Soininen H, Kivipelto M. Muistisairauksien ennaltaehkäisy. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 436-445. Helsinki: Duodecim, 2015.
62 Soininen H, Partanen JV. Kliinis-neurofysiologiset tutkimukset. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 419-425. Helsinki: Duodecim, 2015.
63 Song T, Nie B, Ma E, ..., Liu Y, Luo S, Ma G, Li K. Functional magnetic resonance imaging reveals abnormal brain connectivity in EGR3 gene transfected rat model of schizophrenia. Biochem Biophys Res Commun 2015:460(3):678-683.
64 Steinberg S, Stefansson H, Jonsson T, ..., Helisalmi S, Soininen H, ..., Hiltunen M, ..., Stefansson K. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease. Nat Genet 2015:47(5):445-7.
65 Suhonen NM, Kaivorinne AL, Moilanen V, Bode M, Takalo R, Hänninen T, Remes AM. Slowly progressive frontotemporal lobar degeneration caused by the C9ORF72 repeat expansion: a 20-year follow-up study. Neurocase 2015:21(1):85-89.
66 Taina M, Rissanen V, Hedman M, Jäkälä P, Järvinen V, Vanninen R, Sipola P. Diagnostic Performance of Left Atrial Diameter Measurement in Computed Tomography to Detect Increased Left Atrial Volume. In Vivo 2015:29(4):487-91.
67 Tolppanen AM, Solomon A, Kulmala J, Kåreholt I, Ngandu T, Rusanen M, Laatikainen T, Soininen H, Kivipelto M. Leisure-time physical activity from mid- to late life, body mass index, and risk of dementia. Alzheimers Dement 2015:11(4):434-443.e6.
68 Tolppanen AM, Taipale H, Purmonen T, Koponen M, Soininen H, Hartikainen S. Hospital admissions, outpatient visits and healthcare costs of community-dwellers with Alzheimer's disease. Alzheimers Dement 2015:11(8):955-63.
69 Tomson T, Marson A, Boon P, Canevini MP, Covanis A, Gaily E, Kälviäinen R, Trinka E. Valproate in the treatment of epilepsy in girls and women of childbearing potential. Epilepsia (NY) 2015:56(7):1006-19.
70 Törmälehto SM, Martikainen JA, Väätäinen ST, Hallikainen IT, Hallikainen M, Bell JS, Koivisto AM. Use of Anti-Dementia Drugs in Relation to Change in Cognition, Behavior, and Functioning in Alzheimer's Disease over a Three-Year Period: Kuopio ALSOVA Study. J Alzheimer Dis 2015:48(4):1033-41.
71 Vos SJ, Verhey F, Frölich L, ..., Soininen H, ..., Herukka SK, ..., Visser PJ. Prevalence and prognosis of Alzheimer's disease at the mild cognitive impairment stage. Brain 2015:138(Pt5):1327-38.
72 Välimäki TH, Martikainen JA, Hallikainen IT, Väätäinen ST, Koivisto AM. Depressed Spousal Caregivers Have Psychological Stress Unrelated to the Progression of Alzheimer Disease: A 3-Year Follow-Up Report, Kuopio ALSOVA Study. J Geriatr Psychiatry Neurol 2015:28(4):272-80.
73 Äikiä M, Kälviäinen R. Epilepsia. Kirjassa: Timo Erkinjuntti, Anne Remes, Juha Rinne, Hilkka Soininen, toim. Muistisairaudet, s. 284-289. Helsinki: Duodecim, 2015.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 5.12.2019 Publications Data Base 5.12.2019