Neurologian yksikkö
Department of Neurology

Julkaisut 2017
Publications 2017

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1 Bos I, Verhey FR, Ramakers IHGB, Jakobs HIL, Soininen H, ..., Vos SJB. Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther 2017:9(1):101.
2 Bos I, Vos SJ, Frölich L, ..., Soininen H, Herukka SK, ..., V isser PJ. The frequency and influence of dementia risk factors in prodromal Alzheimer's disease. Neurobiol Aging 2017:56:33-40.
3 Bruun E, Virta LJ, Kälviäinen R, Keränen T. Co-morbidity and clinically significant interactions between antiepileptic drugs and other drugs in elderly patients with newly diagnosed epilepsy. Epilepsy Behav 2017:73:71-76.
4 Ferreira D, Hansson O, Barroso J, ..., Soininen H, et al. The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals. Hippocampus 2017:27(6):653-667.
5 Handels RL, Vos SJ, Kramberger MG, Jelic V, Blennow K, van Buchem M, van der Flier W, Freund-Levi Y, Hampel H, Olde Rikkert M, Oleksik A, Pirtosek Z, Scheltens P, Soininen H, Teunissen C, Tsolaki M, Wallin AK, Winblad B, Verhey FR, Visser PJ. Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. Alzheimers Dement 2017:13(8):903-912.
6 Herukka S-K, Simonsen AH, Andreasen N, Baldeiras I, Bjerke M, Blennow K, Engelborghs S, Frisoni GB, Gabryelewicz T, Galluzzi S, Handels R, Kramberger MG, Kulczynska A, Molinuevo JL, Mroczko B, Nordberg A, Oliveira CR, Otto M, Rinne JO, Rot U, Saka E, Soininen H, Struyfs H, Suardi S, Visser PJ, Winblad B, Zetterberg H, Waldemar G. Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment. Alzheimers Dement 2017:13(3):285-295.
7 Hibar DP, Adams HH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, ..., Soininen Hilkka, ..., Ikram MA. Novel genetic loci associated with hippocampal volume. Nat Commun 2017:8:13624.
8 Hoevenaar-Blom MP, Guillemont J, Ngandu T, Beishuizen CR, Coley N, Moll van Charante EP, Andrieu S, Kivipelto M, Soininen H, Brayne C, Meiller Y, Richard E. Improving data sharing in research with context-free encoded missing data. PLoS ONE 2017:12(9):e0182362.
9 Holtkamp M, Beghi E, Benninger F, Kälviäinen R, Rocamora R, Christensen H. European Stroke Organisation guidelines for the management of post-stroke seizures and epilepsy. European Stroke Journal 2017:2(2):103-115.
10 Huovinen J, Helisalmi S, Paananen J, Laiterä T, Kojoukhova M, Sutela A, Vanninen R, Laitinen M, Rauramaa T, Koivisto AM, Remes AM, Soininen H, Kurki M, Haapasalo A, Jääskeläinen JE, Hiltunen M, Leinonen V. Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus. J Alzheimer Dis 2017:60(3):1077-1085.
11 Huttunen J, Lindgren A, Kurki MI, Huttunen T, Frösen J, Koivisto T, von und zu Fraunberg M, Immonen A, Jääskeläinen JE, Kälviäinen R. Epilepsy-associated long-term mortality after aneurysmal subarachnoid hemorrhage. Neurology 2017:89(3):263-268.
12 Imtiaz B, Taipale H, Tanskanen A, Tiihonen M, Kivipelto M, Heikkinen A, Tiihonen J, Soininen H, Hartikainen S, Tolppanen A. Risk of Alzheimer's disease among users of postmenopausal hormone therapy: A nationwide case-control study. Maturitas 2017:98:7-13.
13 Imtiaz B, Tolppanen AM, Solomon A, Soininen H, Kivipelto M. Estradiol and Cognition in the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) Cohort Study. J Alzheimer Dis 2017:56(2):453-458.
14 Imtiaz B, Tuppurainen M, Rikkonen T, Kivipelto M, Soininen H, Kröger H, Tolppanen A-M. Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study. Neurology 2017:88(11):1062-1068.
15 Junkkari A, Häyrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Luikku A, Jääskeläinen JE, Leinonen V. Health-related quality-of-life outcome in patients with idiopathic normal-pressure hydrocephalus - a 1-year follow-up study. Eur J Neurol 2017:24(1):58-66.
16 Junkkari A, Roine RP, Luikku A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Häyrinen A, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. Why Does the Health-Related Quality of Life in Idiopathic Normal-Pressure Hydrocephalus Fail to Improve Despite the Favorable Clinical Outcome? World Neurosurg 2017:108:356-366.
17 Kantanen A, Kälviäinen R, Parviainen I, Ala-Peijari M, Bäcklund T, Koskenkari J, Laitio R, Reinikainen M. Predictors of hospital and one-year mortality in intensive care patients with refractory status epilepticus: a population-based study. Crit Care 2017:21(1):71.
18 Kantanen A, Reinikainen M, Parviainen I, Kälviäinen R. Long-term outcome of refractory status epilepticus in adults: A retrospective population-based study. Epilepsy Res 2017:133:13-21.
19 Kantanen A-M, Jäkälä P. Tajuton potilas. Kirjassa: Karlsson S, Ala-Kokko T, Pettilä V, Tallgren M, Valtonen M, toim. Tehohoito-opas, 5. uudistettu painos, s. 162-166. Helsinki: Duodecim, 2017.
20 Kantanen A-M, Nerg O, Kokkonen T, Jäkälä P. Aivoinfarktin nykyhoito - toteamisesta toimintaan! Finnanest 2017:50(2):108-114.
21 Khan W, Giampietro V, Banaschewski T, ..., Soininen H, ..., Simmons A, et al. A Multi-Cohort Study of ApoE Epsilon4 and Amyloid-Beta Effects on the Hippocampus in Alzheimer's Disease. J Alzheimer Dis 2017:56(3):1159-1174.
22 Kim M, Nevado-Holgado A, Whiley L, Snowden SG, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Thambisetty M, Dobson RJ, Powell JF, Lupton MK, Simmons A, Velayudhan L, Lovestone S, Proitsi P, Legido-Quigley C. Association between Plasma Ceramides and Phosphatidylcholines and Hippocampal Brain Volume in Late Onset Alzheimer's Disease. J Alzheimer Dis 2017:60(3):809-817.
23 Kimiskidis VK, Tsimpiris A, Ryvlin P, Kalviainen R, Koutroumanidis M, Valentin A, Laskaris N, Kugiumtzis D. TMS combined with EEG in genetic generalized epilepsy: A phase II diagnostic accuracy study. Clin Neurophysiol 2017:128(2):367-381.
24 Kojoukhova M, Vanha KI, Timonen M, Koivisto AM, Nerg O, Rummukainen J, Rauramaa T, Vanninen R, Jääskeläinen JE, Sutela A, Leinonen V. Associations of intracranial pressure with brain biopsy, radiological findings, and shunt surgery outcome in patients with suspected idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien) 2017:159(1):51-61.
25 Kokkonen N, Herukka S, Huilaja L, Kokki M, Koivisto AM, Hartikainen P, Remes AM, Tasanen K. Increased Levels of the Bullous Pemphigoid BP180 Autoantibody Are Associated with More Severe Dementia in Alzheimer's Disease. J Invest Dermatol 2017:137(1):71-76.
26 Kälviäinen R. Epileptinen kohtaus ja status epilepticus (SE). Kirjassa: Karlsson S, Ala-Kokko T, Pettilä V, Tallgren M, Valtonen M, toim. Tehohoito-opas, 5. uudistettu painos, s. 166-171. Helsinki: Duodecim, 2017.
27 Laiterä T, Paananen J, Helisalmi S, Sarajärvi T, Huovinen J, Laitinen M, Rauramaa T, Alafuzoff I, Remes AM, Soininen H, Haapasalo A, Jääskeläinen JE, Leinonen V, Hiltunen M. Effects of Alzheimer's Disease-Associated Risk Loci on Amyloid-beta Accumulation in the Brain of Idiopathic Normal Pressure Hydrocephalus Patients. J Alzheimer Dis 2017:55(3):995-1003.
28 Lautner R, Insel PS, Skillbäck T, Olsson B, Landén M, Frisoni GB, Herukka S-K, Hampel H, Wallin A, Minthon L, Hansson O, Blennow K, Mattsson N, Zetterberg H. Preclinical effects of APOE epsilon4 on cerebrospinal fluid Abeta42 concentrations. Alzheimers Res Ther 2017:9(1):87.
29 Lehtisalo J, Ngandu T, Valve P, Antikainen R, Laatikainen T, Strandberg T, Soininen H, Tuomilehto J, Kivipelto M, Lindström J. Nutrient intake and dietary changes during a 2-year multi-domain lifestyle intervention among older adults: secondary analysis of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) randomised controlled trial. Br J Nutr 2017:118(4):291-302.
30 Liimatainen S, Rellman J, Helén P, Numminen H, Peltola J, Rainesalo S, Jolma P, Koskinen M, Koskinen E, Ylinen A, Roine RO, Honkaniemi J, Siironen J, Herrala L, Haukipuro K, Jäkälä P, Autere J, Luostarinen L, Kuusisto H, Joukainen J, Huhtakangas J, Pieninkeroinen I. Aivovammojen hyvä hoito perustuu yhtenäiseen diagnostiikkaan. Suomen Lääkärilehti 2017:72(33):1700-1701.
31 Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch-Contreras J, Thubron EB, Devall M, Soininen H, ..., Hodges A. Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging 2017:53:36-47.
32 Lupton MK, Benyamin B, Proitsi P, Nyholt DR, Ferreira MA, Montgomery GW, Heath AC, Madden PA, Medland SE, Gordon SD, Lovestone S, Tsolaki M, Kloszewska I, Soininen H, ..., Whitfield JB. No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease. J Alzheimer Dis 2017:59(1):85-99.
33 Marson AG, Bolan A, Mahon J, Little A, Dickson R, Boon P, Depondt C, Martikainen J, Ryvlin P, Kälviäinen R. Cost savings and improved patient outcomes from best management of epilepsy. In: Nutt D, Boyer P, Di luca M, Oertel W, eds. The Value of Treatment of Brain Disorders. Policy White Paper. Towards Optimizing Research and Care for Brain Disorders, 22 June 2017, p. 105-109. EBC Research Project, European Brain Council, 2017.
34 Martiskainen H, Herukka S-K, Stancáková A, Paananen J, Soininen H, Kuusisto J, Laakso M, Hiltunen M. Decreased plasma ß-amyloid in the Alzheimer's disease APP A673T variant carriers. Ann Neurol 2017:82(1):128-132.
35 Martiskainen H, Paldanius KM, Natunen T, Takalo M, Marttinen M, Leskelä S, Huber N, Mäkinen P, Bertling E, Dhungana H, Huuskonen M, Honkakoski P, Hotulainen P, Rilla K, Koistinaho J, Soininen H, Malm T, Haapasalo A, Hiltunen M. DHCR24 exerts neuroprotection upon inflammation-induced neuronal death. J Neuroinflammation 2017:14(1):215.
36 Metsähonkala L, Alapulli H, Arvio M, Hiippala A, Hodgson U, Immonen A, Kananen K, Karvonen M, Kataja J, Kälviäinen R, Leppävirta J, Lähdesmäki T, Nisen H, Pöyhönen M, Vanninen R, Vasara K, Vieira P. Tuberoosiskleroosi - suomalainen diagnoosi- ja seurantasuositus. Suomen Lääkärilehti 2017:72(35):1850-1857.
37 Moradi E, Hallikainen I, Hänninen T, Tohka J, and Alzheimer's Disease Neuroimaging Initiative. Rey's Auditory Verbal Learning Test scores can be predicted from whole brain MRI in Alzheimer's disease. Neuroimage Clin 2017:13:415-427.
38 Muuronen AT, Taina M, Onatsu J, Korhonen M, Pulkki K, Jäkälä P, Vanninen R, Mustonen P. vWF correlates with visceral and pericardial adipose tissue in patients with a recent stroke of suspected cardiogenic etiology. PLoS ONE 2017:12(6):e0178508.
39 Oksanen M, Petersen AJ, Naumenko N, Puttonen K, Lehtonen S, Gubert Olivé M, Shakirzyanova A, Leskelä S, Sarajärvi T, Viitanen M, Rinne JO, Hiltunen M, Haapasalo A, Giniatullin R, Tavi P, Zhang S-C, Kanninen KM, Hämäläinen RH, Koistinaho J. PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease. Stem Cell Rep 2017:9(6):1885-1897.
40 Onatsu J, Taina M, Mustonen P, Hedman M, Muuronen A, Arponen O, Korhonen M, Jäkälä P, Vanninen R, Pulkki K, Mustonen. Soluble Urokinase-type Plasminogen Activator Receptor Predicts All-cause 5-Year Mortality in Ischemic Stroke and TIA. In Vivo 2017:31(3):381-386.
41 Pekkala T, Hall A, Lötjönen J, Mattila J, Soininen H, Ngandu T, Laatikainen T, Kivipelto M, Solomon A. Development of a Late-Life Dementia Prediction Index with Supervised Machine Learning in the Population-Based CAIDE Study. J Alzheimer Dis 2017:55(3):1055-1067.
42 Proitsi P, Kim M, Whiley L, Simmons A, Sattlecker M, Velayudhan L, Lupton MK, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S, Powell JF, Dobson RJ, Legido-Quigley C. Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis. Alzheimers Dement 2017:13(2):140-151.
43 Putaala J, Martinez-Majander N, Saeed S, Yesilot N, Jäkälä P, Nerg O, Tsivgoulis G, ..., Tatlisumak T. Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Triggers, Causes, and Outcome (SECRETO): Rationale and design. European Stroke Journal 2017:2(2):116-125.
44 Rauramaa T, Solomon A, Pikkarainen M, Kälviäinen R, Alafuzoff I. Hippocampal Sclerosis and Epilepsy in Elderly Population. J Alzheimers Dis Parkinsonism 2017:7(5):384.
45 Rehker J, Rodhe J, Nesbitt RR, Boyle EA, Martin BK, Lord J, Karaca I, Naj A, Jessen F, Helisalmi S, Soininen H, Hiltunen M, Ramirez A, Scherer M, Farrer LA, Haines JL, Pericak-Vance MA, Raskind WH, Cruchaga C, Schellenberg GD, et al. Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants. PLoS ONE 2017:12(10):e0185777.
46 Reijs BL, Vos SJ, Soininen H, Lötjonen J, Koikkalainen J, Pikkarainen M, Hall A, Vanninen R, Liu Y, Herukka S-K, Freund-Levi Y, Frisoni GB, Frölich L, Nobili F, et al. Association Between Later Life Lifestyle Factors and Alzheimer's Disease Biomarkers in Non-Demented Individuals: A Longitudinal Descriptive Cohort Study. J Alzheimer Dis 2017:60(4):1387-1395.
47 Reijula E, Pietilä A-M, Halkoaho A, Selander T, Martikainen K, Kälviäinen R, Keränen T. Clinical features of Parkinson's disease patients are associated with therapeutic misconception and willingness to participate in clinical trials. Trials 2017:18(1):444.
48 Reuber M, Kälviäinen R. Seizure-European Journal of Epilepsy at age 25: Where are we now and where we are going? Editorial. Seizure 2017:44:1-3.
49 Roine RO, Jäkälä P. Aivoinfarktin diagnostiikka. Kirjassa: Karlsson S, Ala-Kokko T, Pettilä V, Tallgren M, Valtonen M, toim. Tehohoito-opas, 5. uudistettu painos, s. 171-173. Helsinki: Duodecim, 2017.
50 Roine RO, Jäkälä P. Aivoinfarktin hoito. Kirjassa: Karlsson S, Ala-Kokko T, Pettilä V, Tallgren M, Valtonen M, toim. Tehohoito-opas, 5. uudistettu painos, s. 173-176. Helsinki: Duodecim, 2017.
51 Simonsen AH, Herukka S-K, Andreasen N, ..., Soininen H, ..., Winblad B, Zetterberg H, Waldemar G. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Alzheimers Dement 2017:13(3):274-284.
52 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, ..., Hiltunen M, ..., Soininen H, ..., Helisalmi S, Koivisto AM, Haapasalo A, ..., Seshadri S, Williams J, Schellenberg GD. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet 2017:49(9):1373-1384.
53 Sindi S, Hagman G, Håkansson K, Kulmala J, Nilsen C, Kåreholt I, Soininen H, Solomon A, Kivipelto M. Midlife Work-Related Stress Increases Dementia Risk in Later Life: The CAIDE 30-Year Study. J Gerontol B Psychol Sci Soc Sci 2017:72(6):1044-1053.
54 Sindi S, Kåreholt I, Solomon A, Hooshmand B, Soininen H, Kivipelto M. Midlife work-related stress is associated with late-life cognition. J Neurol 2017:264(9):1996-2002.
55 Sindi S, Ngandu T, Hovatta I, Kåreholt I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Solomon A, for the FINGER study group. Baseline Telomere Length and Effects of a Multidomain Lifestyle Intervention on Cognition: The FINGER Randomized Controlled Trial. J Alzheimer Dis 2017:59(4):1459-1470.
56 Soininen H, Solomon A, Jelle Visser P, Hendrix SB, Blennow K, Kivipelto M, Hartmann T. 24-month intervention with a specific multinutrient in people with prodromal Alzheimer's disease (LipiDiDiet): a randomised, double-blind, controlled trial. Lancet Neurol 2017:16(12):965-975.
57 Sokka A, Olsen P, Kirjavainen J, Harju M, Keski-Nisula L, Räisänen S, Heinonen S, Kälviäinen R. Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study. Epilepsia Open 2017:2(1):76-83.
58 Stephen R, Liu Y, Ngandu T, Rinne JO, Kemppainen N, Parkkola R, Laatikainen T, Paajanen T, Hänninen T, Strandberg T, Antikainen R, Tuomilehto J, Keinänen Kiukaanniemi S, Vanninen R, Helisalmi S, Levälahti E, Kivipelto M, Soininen H, Solomon A. Associations of CAIDE Dementia Risk Score with MRI, PIB-PET measures, and cognition. J Alzheimer Dis 2017:59(2):695-705.
59 Suhonen N, Haanpää RM, Korhonen V, Jokelainen J, Pitkäniemi A, Heikkinen A, Krüger J, Hartikainen P, Helisalmi S, Hiltunen M, Hänninen T, Remes AM. Neuropsychological Profile in the C9ORF72 Associated Behavioral Variant Frontotemporal Dementia. J Alzheimer Dis 2017:58(2):479-489.
60 Suhonen N-M, Hallikainen I, Hänninen T, Jokelainen J, Krüger J, Hall A, Pikkarainen M, Soininen H, Remes AM. The Modified Frontal Behavioral Inventory (FBI-mod) for Patients with Frontotemporal Lobar Degeneration, Alzheimer's Disease, and Mild Cognitive Impairment. J Alzheimer Dis 2017:56(4):1241-1251.
61 Tong T, Ledig C, Guerrero R, Schuh A, Koikkalainen J, Tolonen A, Rhodius H, Barkhof F, Tijms B, Lemstra AW, Soininen H, Remes AM, Waldemar G, Hasselbalch S, Mecocci P, Baroni M, Lötjönen J, van der Flier W, Rueckert D. Five-class differential diagnostics of neurodegenerative diseases using random undersampling boosting. Neuroimage Clin 2017:15:613-624.
62 Trinka E, Kälviäinen R. 25 years of advances in the definition, classification and treatment of status epilepticus. Seizure 2017:44:65-73.
63 Törmälehto S, Martikainen J, Bell JS, Hallikainen I, Koivisto AM. Use of psychotropic medications in relation to neuropsychiatric symptoms, cognition and functional performance in Alzheimer's disease over a three-year period: Kuopio ALSOVA study. Int Psychogeriatr 2017:29(10):1723-33.
64 Westwood S, Liu B, Baird AL, Anand S, Nevado-Holgado AJ, Newby D, Pikkarainen M, Hallikainen M, Kuusisto J, Streffer JR, Novak G, Blennow K, Andreasson U, Zetterberg H, Smith U, Laakso M, Soininen H, Lovestone S. The influence of insulin resistance on cerebrospinal fluid and plasma biomarkers of Alzheimer's pathology. Alzheimers Res Ther 2017:9(1):31.
65 Ylönen S, Siitonen A, Nalls MA, Ylikotila P, Autere J, Eerola-Rautio J, Gibbs R, Hiltunen M, Tienari PJ, Soininen H, Singleton AB, Majamaa K. Genetic risk factors in Finnish patients with Parkinson's disease. Parkinsonism & Related Disorders 2017:45:39-43.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 5.12.2019 Publications Data Base 5.12.2019