Neurologian yksikkö
Department of Neurology

Julkaisut 2018
Publications 2018

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1 Abou-Khalili B, Auce P, Avbersek A, ..., Kälviäinen R, Kantanen AM, ..., Zimprich F. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nat Commun 2018:9(1):5269.
2 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, ..., Kälviäinen R, ..., Murray R. Analysis of shared heritability in common disorders of the brain. Science 2018:360(6395):eaap8757.
3 Anwer M, Bolkvadze T, Ndode-Ekane XE, Puhakka N, Rauramaa T, Leinonen V, van Vliet EA, Swaab DF, Haapasalo A, Leskelä S, Bister N, Malm T, Carlson S, Aronica E, Pitkänen A. Sushi repeat-containing protein X-linked 2: A novel phylogenetically conserved hypothalamo-pituitary protein. J Comp Neurol 2018:526(11):1806-1819.
4 Barbera M, Mangialasche F, Jongstra S, Guillemont J, Ngandu T, Beishuizen C, Coley N, Brayne C, Andrieu S, Richard E, Soininen H, Kivipelto M, for the HATICE study group. Designing an Internet-Based Multidomain Intervention for the Prevention of Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial. J Alzheimer Dis 2018:62(2):649-663.
5 Baud MO, Perneger T, Rácz A, ..., Kälviäinen R, ..., Seeck M. European trends in epilepsy surgery. Neurology 2018:91(2):e96-e106.
6 Bos I, Verhey FR, Ramakers IH, Jacobs HI, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Rikkert MOlde, van der Flier WM, Scheltens P, Aalten P, Visser PJelle, Vos SJ. Correction to: Cerebrovascular and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther 2018:10(1):56.
7 Cajanus A, Hall A, Koikkalainen J, Solje E, Tolonen A, Urhemaa T, Liu Y, Haanpää RM, Hartikainen P, Helisalmi S, Korhonen V, Rueckert D, Hasselbalch S, Waldemar G, Mecocci P, Vanninen R, van Gils M, Soininen H, Lötjönen J, Remes AM. Automatic MRI Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis. Dement Geriatr Cogn Disord Extra 2018:8(1):51-59.
8 Ferlisi M, Hocker S, Trinka E, ..., Kälviäinen R, ..., Reinikainen M. Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit. Epilepsia (NY) 2018:59 Suppl 2:100-107.
9 Haapalinna F, Kokki M, Jääskeläinen O, Hallikainen M, Helisalmi S, Koivisto A, Kokki H, Paajanen T, Penttinen J, Pikkarainen M, Rautiainen M, Soininen H, Solje E, Remes AM, Herukka S. Subtle Cognitive Impairment and Alzheimer's Disease-Type Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects. J Alzheimer Dis 2018:62(1):165-174.
10 Hallikainen I, Hongisto K, Välimäki T, Hänninen T, Martikainen J, Koivisto AM. The Progression of Neuropsychiatric Symptoms in Alzheimer's Disease During a Five-Year Follow-Up: Kuopio ALSOVA Study. J Alzheimer Dis 2018:61(4):1367-1376.
11 Helmstaedter C, Beghi E, Elger CE, Kälviäinen R, Malmgren K, May TW, Perucca E, Trinka E, Witt JA. No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia risk-An analysis of Finnish health register and German health insurance data. Epilepsia (NY) 2018:59(7):1303-1306.
12 Helmstaedter C, Beghi E, Elger CE, Kälviäinen R, Malmgren K, May TW, Perucca E, Trinka E, Witt JA. No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia. J Am Geriatr Soc 2018:66(9):1850-1852.
13 Hongisto K, Hallikainen I, Selander T, Törmälehto S, Väätäinen S, Martikainen J, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. Quality of Life in relation to neuropsychiatric symptoms in Alzheimer's disease: 5-year prospective ALSOVA cohort study. Int J Geriatr Psychiatry 2018:33(1):47-57.
14 Hynynen J, Pokka T, Komulainen-Ebrahim J, Myllynen P, Kärppä M, Pylvänen L, Kälviäinen R, Sokka A, Jyrkilä A, Lähdetie J, Haataja L, Mäkitalo A, Ylikotila P, ...., Uusimaa J. Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1 are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. Epilepsia (NY) 2018:59(11):2125-2136.
15 Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, ..., Herukka SK, ..., Soininen H, ..., Zetterberg H. Association of Cerebral Amyloid-[beta] Aggregation With Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry 2018:75(1):84-95.
16 Julkunen P, Löfberg O, Kallioniemi E, Hyppönen J, Kälviäinen R, Mervaala E. Abnormal motor cortical adaptation to external stimulus in Unverricht-Lundborg disease (progressive myoclonus type 1, EPM1). J Neurophysiol 2018:120:617-623.
17 Karhi S, Nerg O, Miettinen T, Mäkipaakkanen E, Taina M, Manninen H, Vanninen R, Jäkälä P. Mechanical Thrombectomy of Large Artery Occlusion Is Beneficial in Octogenarians. In Vivo 2018:32(5):1223-1230.
18 Katisko K, Haapasalo A, Koivisto A, Krüger J, Hartikainen P, Korhonen V, Helisalmi S, Herukka S-K, Remes AM, Solje E. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration. J Alzheimer Dis 2018:62(2):789-794.
19 Katisko K, Kokkonen N, Krüger J, Hartikainen P, Koivisto AM, Helisalmi S, Korhonen VE, Kokki M, Tuusa J, Herukka SK, Solje E, Haapasalo A, Tasanen K, Remes AM. The Association Between Frontotemporal Lobar Degeneration and Bullous Pemphigoid. J Alzheimer Dis 2018:66(2):743-750.
20 Katisko K, Solje E, Koivisto AM, Krüger J, Kinnunen T, Hartikainen P, Helisalmi S, Korhonen V, Herukka S-K, Haapasalo A, Remes AM. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat expansion carriers and non-carriers. J Neuroimmunol 2018:321:29-35.
21 Kemppainen N, Johansson J, Teuho J, Parkkola R, Joutsa J, Ngandu T, Solomon A, Stephen R, Liu Y, Hänninen T, Paajanen T, Laatikainen T, Soininen H, Jula A, Rokka J, Rissanen E, Vahlberg T, Peltoniemi J, Kivipelto M, Rinne JO. Brain amyloid load and its associations with cognition and vascular risk factors in FINGER Study. Neurology 2018:90(3):e206-e213.
22 Koivisto AM, Paajanen T, Rinne J, Hokkanen L, Vanninen R, Herukka S, Lötjönen J, Hallikainen M. Alzheimerin taudin varhainen tunnistaminen. Duodecim 2018:134(24):2519-2528.
23 Korhonen VE, Helisalmi S, Jokinen A, ..., Rinne J, Ronkainen A, Kauppinen M, Junkkari A, Hiltunen M, Soininen H, Kurki M, Jääskeläinen JE, Koivisto AM, Sato H, Kato T, Remes AM, Eide PK, Leinonen V. Copy number loss in SFMBT1 is common among Finnish and Norwegian patients with iNPH. Neurol Genet 2018:4(6):e291.
24 Kälviäinen R, Straus S, Dogne JM, Bakchine S, Haas M. Reducing valproate use in women with epilepsy. Lancet Neurol 2018:17(7):580-581.
25 Leal NS, Dentoni G, Schreiner B, Kämäräinen OP, Partanen N, Herukka SK, Koivisto AM, Hiltunen M, Rauramaa T, Leinonen V, Ankarcrona M. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients. Acta Neuropathol Commun 2018:6(1):102.
26 Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto AM, Jääskeläinen JE, Hiltunen M, Herukka SK, ..., Rinne JO. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-[beta] Plaques and Tau in Brain Biopsies. J Alzheimer Dis 2018:64(1):171-179.
27 Leskelä S, Takalo M, Marttinen M, Huber N, Paananen J, Mitra V, Rauramaa T, Mäkinen P, Leinonen V, Soininen H, Pike I, Remes AM, Hiltunen M, Haapasalo A. Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in Human Cells and Brain Samples. J Alzheimer Dis 2018:62(1):269-278.
28 Marengoni A, Rizzuto D, Fratiglioni L, Antikainen R, Laatikainen T, Lehtisalo J, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training, and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled Trial. J Am Med Dir Assoc 2018:19(4):355-360.e1.
29 Martiskainen H, Takalo M, Solomon A, Stancáková A, Marttinen M, Natunen T, Haapasalo A, Herukka S-K, Kuusisto J, Soininen H, Kivipelto M, Laakso M, Hiltunen M. Decreased plasma C-reactive protein levels in in APOE [epsilon]4 allele carriers. Ann Clin Transl Neurol 2018:5(10):1229-1240.
30 Mattsson N, Groot C, Jansen WJ, Landau SM, ..., Herukka SK, ..., Ossenkoppele R. Prevalence of the apolipoprotein E [epsilon]4 allele in amyloid [beta] positive subjects across the spectrum of Alzheimer's disease. Alzheimers Dement 2018:14(7):913-924.
31 Mårtensson G, Pereira JB, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Volpe G, Westman E. Stability of graph theoretical measures in structural brain networks in Alzheimer's disease. Sci Rep 2018:8(1):11592.
32 Oliveira F, Leuzy A, Castelhano J, Chiotis K, ..., Herukka S-K, ..., Castelo-Branco M. Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF concentrations of A[beta] species. Neuroimage Clin 2018:20:603-610.
33 Oresic M, Anderson G, Mattila I, Manoucheri M, Soininen H, Hyötyläinen T, Basignani C. Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor. Front Neurosci 2018:11:747.
34 Poulakis K, Pereira JB, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund L-O, Westman E. Heterogeneous patterns of brain atrophy in Alzheimer's disease. Neurobiol Aging 2018:65:98-108.
35 Pyykkö OT, Nerg O, Niskasaari H-M, Niskasaari T, Koivisto AM, Hiltunen M, Pihlajamäki J, Rauramaa T, Kojoukhova M, Alafuzoff I, Soininen H, Jääskeläinen JE, Leinonen V. Incidence, Comorbidities, and Mortality in Idiopathic Normal Pressure Hydrocephalus. World Neurosurg 2018:112:e624-e631.
36 Ramos de Matos M, Ferreira C, Herukka S, Soininen H, Janeiro A, Santana I, Baldeiras I, Almeida MR, Lleó A, Dols-Icardo O, Alcolea D, Benussi L, ..., Martins M. Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. J Alzheimer Dis 2018:66(2):639-652.
37 Reijula E, Halkoaho A, Pietilä A-M, Selander T, Martikainen K, Kälviäinen R, Keränen T. Comparable indicators of therapeutic misconception between epilepsy or Parkinson’s disease patients between those with clinical trial experience and trial non-participants . Seizure 2018:60:61-67.
38 Rosenberg A, Ngandu T, Rusanen M, Antikainen R, Bäckman L, Havulinna S, Hänninen T, Laatikainen T, Lehtisalo J, Levälahti E, Lindström J, Paajanen T, Peltonen M, Soininen H, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Solomon A, Kivipelto M. Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimers Dement 2018:14(3):263-270.
39 Saari T, Hallikainen I, Hänninen T, Räty H, Koivisto A. Relationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study. J Alzheimer Dis 2018:64(1):269-279.
40 Shorvon S, Bermejo PE, Gibbs AA, Huberfeld G, Kälviäinen R. Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection. Epilepsy Behav 2018:82(2018):91-103.
41 Sindi S, Johansson L, Skoog J, Mattsson AD, Sjöberg L, Wang H, Fratiglioni L, Kulmala J, Soininen H, Solomon A, Johansson B, Skoog I, Kivipelto M, Kåreholt I. Sleep disturbances and later cognitive status: a multi-centre study. Sleep Med 2018:52:26-33.
42 Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, Ngandu T, Kivipelto M. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life. Nutrients 2018:10(11):E1649.
43 Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang H-X, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M. Sleep disturbances and dementia risk: A multicenter study. Alzheimers Dement 2018:14(10):1235-1242.
44 Sipilä S, Tirkkonen A, Hänninen T, Laukkanen P, Alen M, Fielding RA, Kivipelto M, Kokko K, Kulmala J, Rantanen T, Sihvonen SE, Sillanpää E, Stigsdotter-Neely A, Törmäkangas T. Promoting safe walking among older people: the effects of a physical and cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): design and methods of a randomize. BMC Geriatrics 2018:18(1):215.
45 Soininen H. Alzheimerin taudin haaste - patofysiologiasta hoidon tutkimukseen. Duodecim 2018:134(24):2509-2510.
46 Solomon A, Turunen H, Ngandu T, Peltonen M, Levälahti E, Helisalmi S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Pajala S, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial. JAMA Neurol 2018:75(4):462-470.
47 Sulkava S, Muggalla P, Sulkava R, Ollila HM, Peuralinna T, Myllykangas L, Kaivola K, Stone DJ, Traynor BJ, Renton AE, Rivera AM, Helisalmi S, Soininen H, Polvikoski T, Hiltunen M, Tienari PJ, Huttunen HJ, Paunio T. Melatonin receptor type 1A gene linked to Alzheimer's disease in old age. Sleep 2018:41(7):10.1093/sleep/zsy103.
48 Teunissen CE, Otto M, Engelborghs S, Herukka S-K, Lehmann S, ..., Blennow K. White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation. Alzheimers Res Ther 2018:10(1):30.
49 Tolonen A, Rhodius-Meester HF, Bruun M, Koikkalainen J, Barkhof F, Lemstra AW, Koene T, Scheltens P, Teunissen CE, Tong T, Guerrero R, Schuh A, Ledig C, Baroni M, Rueckert D, Soininen H, Remes AM, ... Data-Driven Differential Diagnosis of Dementia Using Multiclass Disease State Index Classifier. Front Aging Neurosci 2018:10:111.
50 Tomson T, Battino D, Bonizzoni E, ..., Kälviäinen R, ..., Zarifi-Oskoie M. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol 2018:17(6):530-538.
51 Vaskivuo L, Hokkanen L, Hänninen T, Antikainen R, Bäckman L, Laatikainen T, Paajanen T, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Associations between Prospective and Retrospective Subjective Memory Complaints and Neuropsychological Performance in Older Adults: The Finger Study. J Int Neuropsychol Soc 2018:24(10):1099-1109.
52 Vermunt L, Veal CD, ter Meulen L, Chrysostomou C, van der Flier W, Frisoni GB, Guessous I, Kivipelto M, Marizzoni M, Martinez-Lage P, Molinuevo JL, Porteous D, Ritchie K, Scheltens P, Ousset P-J, Ritchie CW, Luscan G, Brookes AJ, Visser PJ. European Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials. Alzheimers Dement 2018:14(6):837-842.
53 Virta LJ, Kälviäinen R, Villikka K, Keränen T. Declining trend in valproate use in Finland among females of childbearing age in 2012-2016 - a nationwide registry-based outpatient study. Eur J Neurol 2018:25(6):869-874.
54 Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, Absil J, Alhusaini S, Alvim MKM, Auvinen P, ..., Saavalainen T, ..., Kälviäinen R, ..., Sisodiya SM. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study. Brain 2018:141(2):391-408.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 5.12.2019 Publications Data Base 5.12.2019