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Abou-Khalili B, Auce P, Avbersek A, ..., Kälviäinen R, Kantanen AM, ..., Zimprich F. Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies. Nat Commun 2018:9(1):5269.
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Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, ..., Kälviäinen R, ..., Murray R. Analysis of shared heritability in common disorders of the
brain. Science 2018:360(6395):eaap8757.
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3 |
Anwer M, Bolkvadze T, Ndode-Ekane XE, Puhakka N, Rauramaa T, Leinonen V, van Vliet EA, Swaab DF, Haapasalo A, Leskelä S, Bister N, Malm T, Carlson S, Aronica E, Pitkänen A. Sushi repeat-containing protein X-linked 2: A novel phylogenetically
conserved hypothalamo-pituitary protein. J Comp Neurol 2018:526(11):1806-1819.
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Barbera M, Mangialasche F, Jongstra S, Guillemont J, Ngandu T, Beishuizen C, Coley N, Brayne C, Andrieu S, Richard E, Soininen H, Kivipelto M, for the HATICE study group. Designing an Internet-Based Multidomain Intervention for the Prevention of
Cardiovascular Disease and Cognitive Impairment in Older Adults: The HATICE Trial. J Alzheimers Dis 2018:62(2):649-663.
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Baud MO, Perneger T, Rácz A, ..., Kälviäinen R, ..., Seeck M. European trends in epilepsy surgery. Neurology 2018:91(2):e96-e106.
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Bos I, Verhey FR, Ramakers IH, Jacobs HI, Soininen H, Freund-Levi Y, Hampel H, Tsolaki M, Wallin ÅK, van Buchem MA, Oleksik A, Verbeek MM, Rikkert MOlde, van der Flier WM, Scheltens P, Aalten P, Visser PJelle, Vos SJ. Correction to: Cerebrovascular
and amyloid pathology in predementia stages: the relationship with neurodegeneration and cognitive decline. Alzheimers Res Ther 2018:10(1):56.
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Cajanus A, Hall A, Koikkalainen J, Solje E, Tolonen A, Urhemaa T, Liu Y, Haanpää RM, Hartikainen P, Helisalmi S, Korhonen V, Rueckert D, Hasselbalch S, Waldemar G, Mecocci P, Vanninen R, van Gils M, Soininen H, Lötjönen J, Remes AM. Automatic MRI
Quantifying Methods in Behavioral-Variant Frontotemporal Dementia Diagnosis. Dement Geriatr Cogn Disord Extra 2018:8(1):51-59.
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Ferlisi M, Hocker S, Trinka E, ..., Kälviäinen R, ..., Reinikainen M. Etiologies and characteristics of refractory status epilepticus cases in different areas of the world: Results from a global audit. Epilepsia (NY) 2018:59 Suppl
2:100-107.
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Haapalinna F, Kokki M, Jääskeläinen O, Hallikainen M, Helisalmi S, Koivisto A, Kokki H, Paajanen T, Penttinen J, Pikkarainen M, Rautiainen M, Soininen H, Solje E, Remes AM, Herukka S. Subtle Cognitive Impairment and Alzheimer's Disease-Type
Pathological Changes in Cerebrospinal Fluid are Common Among Neurologically Healthy Subjects. J Alzheimers Dis 2018:62(1):165-174.
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Hallikainen I, Hongisto K, Välimäki T, Hänninen T, Martikainen J, Koivisto AM. The Progression of Neuropsychiatric Symptoms in Alzheimer's Disease During a Five-Year Follow-Up: Kuopio ALSOVA Study. J Alzheimers Dis 2018:61(4):1367-1376.
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Helmstaedter C, Beghi E, Elger CE, Kälviäinen R, Malmgren K, May TW, Perucca E, Trinka E, Witt JA. No proof of a causal relationship between antiepileptic drug treatment and incidence of dementia. Comment on: Use of antiepileptic drugs and dementia
risk-An analysis of Finnish health register and German health insurance data. Epilepsia (NY) 2018:59(7):1303-1306.
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Helmstaedter C, Beghi E, Elger CE, Kälviäinen R, Malmgren K, May TW, Perucca E, Trinka E, Witt JA. No Evidence of a Causal Role of Antiepileptic Drug Treatment with Regard to the Development of Dementia. J Am Geriatr Soc
2018:66(9):1850-1852.
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Hongisto K, Hallikainen I, Selander T, Törmälehto S, Väätäinen S, Martikainen J, Välimäki T, Hartikainen S, Suhonen J, Koivisto AM. Quality of Life in relation to neuropsychiatric symptoms in Alzheimer's disease: 5-year prospective ALSOVA cohort
study. Int J Geriatr Psychiatry 2018:33(1):47-57.
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Hynynen J, Pokka T, Komulainen-Ebrahim J, Myllynen P, Kärppä M, Pylvänen L, Kälviäinen R, Sokka A, Jyrkilä A, Lähdetie J, Haataja L, Mäkitalo A, Ylikotila P, ...., Uusimaa J. Variants p.Q1236H and p.E1143G in mitochondrial DNA polymerase gamma POLG1
are not associated with increased risk for valproate-induced hepatotoxicity or pancreatic toxicity: A retrospective cohort study of patients with epilepsy. Epilepsia (NY) 2018:59(11):2125-2136.
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Jansen WJ, Ossenkoppele R, Tijms BM, Fagan AM, Hansson O, Klunk WE, van der Flier WM, Villemagne VL, Frisoni GB, Fleisher AS, Lleó A, ..., Herukka SK, ..., Soininen H, ..., Zetterberg H. Association of Cerebral Amyloid-[beta] Aggregation With
Cognitive Functioning in Persons Without Dementia. JAMA Psychiatry 2018:75(1):84-95.
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Julkunen P, Löfberg O, Kallioniemi E, Hyppönen J, Kälviäinen R, Mervaala E. Abnormal motor cortical adaptation to external stimulus in Unverricht-Lundborg disease (progressive myoclonus type 1, EPM1). J Neurophysiol 2018:120:617-623.
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17 |
Karhi S, Nerg O, Miettinen T, Mäkipaakkanen E, Taina M, Manninen H, Vanninen R, Jäkälä P. Mechanical Thrombectomy of Large Artery Occlusion Is Beneficial in Octogenarians. In Vivo 2018:32(5):1223-1230.
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Katisko K, Haapasalo A, Koivisto A, Krüger J, Hartikainen P, Korhonen V, Helisalmi S, Herukka S-K, Remes AM, Solje E. Low Prevalence of Cancer in Patients with Frontotemporal Lobar Degeneration. J Alzheimers Dis 2018:62(2):789-794.
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Katisko K, Kokkonen N, Krüger J, Hartikainen P, Koivisto AM, Helisalmi S, Korhonen VE, Kokki M, Tuusa J, Herukka SK, Solje E, Haapasalo A, Tasanen K, Remes AM. The Association Between Frontotemporal Lobar Degeneration and Bullous Pemphigoid. J
Alzheimers Dis 2018:66(2):743-750.
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20 |
Katisko K, Solje E, Koivisto AM, Krüger J, Kinnunen T, Hartikainen P, Helisalmi S, Korhonen V, Herukka S-K, Haapasalo A, Remes AM. Prevalence of immunological diseases in a Finnish frontotemporal lobar degeneration cohort with the C9orf72 repeat
expansion carriers and non-carriers. J Neuroimmunol 2018:321:29-35.
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21 |
Kemppainen N, Johansson J, Teuho J, Parkkola R, Joutsa J, Ngandu T, Solomon A, Stephen R, Liu Y, Hänninen T, Paajanen T, Laatikainen T, Soininen H, Jula A, Rokka J, Rissanen E, Vahlberg T, Peltoniemi J, Kivipelto M, Rinne JO. Brain amyloid load and
its associations with cognition and vascular risk factors in FINGER Study. Neurology 2018:90(3):e206-e213.
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22 |
Koivisto AM, Paajanen T, Rinne J, Hokkanen L, Vanninen R, Herukka S, Lötjönen J, Hallikainen M. Alzheimerin taudin varhainen tunnistaminen. Duodecim 2018:134(24):2519-2528.
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Korhonen VE, Helisalmi S, Jokinen A, ..., Rinne J, Ronkainen A, Kauppinen M, Junkkari A, Hiltunen M, Soininen H, Kurki M, Jääskeläinen JE, Koivisto AM, Sato H, Kato T, Remes AM, Eide PK, Leinonen V. Copy number loss in SFMBT1 is common among Finnish
and Norwegian patients with iNPH. Neurol Genet 2018:4(6):e291.
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24 |
Kurl S, Laukkanen JA, Lonnroos E, Remes AM, Soininen H. Cardiorespiratory fitness and risk of dementia: a prospective population-based cohort study. Age Ageing 2018:47(4):611-614.
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Kälviäinen R, Straus S, Dogne JM, Bakchine S, Haas M. Reducing valproate use in women with epilepsy. Lancet Neurol 2018:17(7):580-581.
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26 |
Leal NS, Dentoni G, Schreiner B, Kämäräinen OP, Partanen N, Herukka SK, Koivisto AM, Hiltunen M, Rauramaa T, Leinonen V, Ankarcrona M. Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal
pressure hydrocephalus patients. Acta Neuropathol Commun 2018:6(1):102.
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27 |
Leinonen V, Rauramaa T, Johansson J, Bottelbergs A, Tesseur I, van der Ark P, Pemberton D, Koivisto AM, Jääskeläinen JE, Hiltunen M, Herukka SK, ..., Rinne JO. S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus
in Relation to Confirmed Amyloid-[beta] Plaques and Tau in Brain Biopsies. J Alzheimers Dis 2018:64(1):171-179.
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28 |
Leskelä S, Takalo M, Marttinen M, Huber N, Paananen J, Mitra V, Rauramaa T, Mäkinen P, Leinonen V, Soininen H, Pike I, Remes AM, Hiltunen M, Haapasalo A. Interrelationship between the Levels of C9orf72 and Amyloid-ß Protein Precursor and Amyloid-ß in
Human Cells and Brain Samples. J Alzheimers Dis 2018:62(1):269-278.
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29 |
Marengoni A, Rizzuto D, Fratiglioni L, Antikainen R, Laatikainen T, Lehtisalo J, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. The Effect of a 2-Year Intervention Consisting of Diet, Physical Exercise, Cognitive Training,
and Monitoring of Vascular Risk on Chronic Morbidity-the FINGER Randomized Controlled Trial. J Am Med Dir Assoc 2018:19(4):355-360.e1.
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30 |
Martiskainen H, Takalo M, Solomon A, Stancáková A, Marttinen M, Natunen T, Haapasalo A, Herukka S-K, Kuusisto J, Soininen H, Kivipelto M, Laakso M, Hiltunen M. Decreased plasma C-reactive protein levels in in APOE [epsilon]4 allele carriers. Ann
Clin Transl Neurol 2018:5(10):1229-1240.
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31 |
Mattsson N, Groot C, Jansen WJ, Landau SM, ..., Herukka SK, ..., Ossenkoppele R. Prevalence of the apolipoprotein E [epsilon]4 allele in amyloid [beta] positive subjects across the spectrum of Alzheimer's disease. Alzheimers Dement
2018:14(7):913-924.
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32 |
Mårtensson G, Pereira JB, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Volpe G, Westman E. Stability of graph theoretical measures in structural brain networks in Alzheimer's disease. Sci Rep
2018:8(1):11592.
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33 |
Oliveira F, Leuzy A, Castelhano J, Chiotis K, ..., Herukka S-K, ..., Castelo-Branco M. Data driven diagnostic classification in Alzheimer's disease based on different reference regions for normalization of PiB-PET images and correlation with CSF
concentrations of A[beta] species. Neuroimage Clin 2018:20:603-610.
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34 |
Oresic M, Anderson G, Mattila I, Manoucheri M, Soininen H, Hyötyläinen T, Basignani C. Targeted Serum Metabolite Profiling Identifies Metabolic Signatures in Patients with Alzheimer's Disease, Normal Pressure Hydrocephalus and Brain Tumor. Front
Neurosci 2018:11:747.
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35 |
Poulakis K, Pereira JB, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Simmons A, Wahlund L-O, Westman E. Heterogeneous patterns of brain atrophy in Alzheimer's disease. Neurobiol Aging 2018:65:98-108.
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36 |
Pyykkö OT, Nerg O, Niskasaari H-M, Niskasaari T, Koivisto AM, Hiltunen M, Pihlajamäki J, Rauramaa T, Kojoukhova M, Alafuzoff I, Soininen H, Jääskeläinen JE, Leinonen V. Incidence, Comorbidities, and Mortality in Idiopathic Normal
Pressure Hydrocephalus. World Neurosurg 2018:112:e624-e631.
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37 |
Ramos de Matos M, Ferreira C, Herukka S, Soininen H, Janeiro A, Santana I, Baldeiras I, Almeida MR, Lleó A, Dols-Icardo O, Alcolea D, Benussi L, ..., Martins M. Quantitative Genetics Validates Previous Genetic Variants and Identifies Novel Genetic
Players Influencing Alzheimer's Disease Cerebrospinal Fluid Biomarkers. J Alzheimers Dis 2018:66(2):639-652.
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38 |
Reijula E, Halkoaho A, Pietilä A-M, Selander T, Martikainen K, Kälviäinen R, Keränen T. Comparable indicators of therapeutic misconception between epilepsy or Parkinson’s disease patients between those with clinical trial experience and trial
non-participants . Seizure 2018:60:61-67.
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39 |
Rosenberg A, Ngandu T, Rusanen M, Antikainen R, Bäckman L, Havulinna S, Hänninen T, Laatikainen T, Lehtisalo J, Levälahti E, Lindström J, Paajanen T, Peltonen M, Soininen H, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Solomon A, Kivipelto M.
Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial. Alzheimers Dement 2018:14(3):263-270.
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40 |
Saari T, Hallikainen I, Hänninen T, Räty H, Koivisto A. Relationships between Cognition and Activities of Daily Living in Alzheimer's Disease During a 5-Year Follow-Up: ALSOVA Study. J Alzheimers Dis 2018:64(1):269-279.
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41 |
Shorvon S, Bermejo PE, Gibbs AA, Huberfeld G, Kälviäinen R. Antiepileptic drug treatment of generalized tonic-clonic seizures: An evaluation of regulatory data and five criteria for drug selection. Epilepsy Behav 2018:82(2018):91-103.
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42 |
Sindi S, Johansson L, Skoog J, Mattsson AD, Sjöberg L, Wang H, Fratiglioni L, Kulmala J, Soininen H, Solomon A, Johansson B, Skoog I, Kivipelto M, Kåreholt I. Sleep disturbances and later cognitive status: a multi-centre study. Sleep Med
2018:52:26-33.
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43 |
Sindi S, Kåreholt I, Eskelinen M, Hooshmand B, Lehtisalo J, Soininen H, Ngandu T, Kivipelto M. Healthy Dietary Changes in Midlife Are Associated with Reduced Dementia Risk Later in Life. Nutrients 2018:10(11):E1649.
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Sindi S, Kåreholt I, Johansson L, Skoog J, Sjöberg L, Wang H-X, Johansson B, Fratiglioni L, Soininen H, Solomon A, Skoog I, Kivipelto M. Sleep disturbances and dementia risk: A multicenter study. Alzheimers Dement 2018:14(10):1235-1242.
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Sipilä S, Tirkkonen A, Hänninen T, Laukkanen P, Alen M, Fielding RA, Kivipelto M, Kokko K, Kulmala J, Rantanen T, Sihvonen SE, Sillanpää E, Stigsdotter-Neely A, Törmäkangas T. Promoting safe walking among older people: the effects of a physical and
cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): design and methods of a randomize. BMC Geriatr 2018:18(1):215.
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Soininen H. Alzheimerin taudin haaste - patofysiologiasta hoidon tutkimukseen. Duodecim 2018:134(24):2509-2510.
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Solomon A, Turunen H, Ngandu T, Peltonen M, Levälahti E, Helisalmi S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Pajala S, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto
M. Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial. JAMA Neurol 2018:75(4):462-470.
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Sulkava S, Muggalla P, Sulkava R, Ollila HM, Peuralinna T, Myllykangas L, Kaivola K, Stone DJ, Traynor BJ, Renton AE, Rivera AM, Helisalmi S, Soininen H, Polvikoski T, Hiltunen M, Tienari PJ, Huttunen HJ, Paunio T. Melatonin receptor type 1A gene
linked to Alzheimer's disease in old age. Sleep 2018:41(7):10.1093/sleep/zsy103.
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49 |
Teunissen CE, Otto M, Engelborghs S, Herukka S-K, Lehmann S, ..., Blennow K. White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation. Alzheimers Res Ther
2018:10(1):30.
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50 |
Tolonen A, Rhodius-Meester HF, Bruun M, Koikkalainen J, Barkhof F, Lemstra AW, Koene T, Scheltens P, Teunissen CE, Tong T, Guerrero R, Schuh A, Ledig C, Baroni M, Rueckert D, Soininen H, Remes AM, ... Data-Driven Differential Diagnosis of Dementia
Using Multiclass Disease State Index Classifier. Front Aging Neurosci 2018:10:111.
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51 |
Tomson T, Battino D, Bonizzoni E, ..., Kälviäinen R, ..., Zarifi-Oskoie M. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol
2018:17(6):530-538.
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52 |
Vaskivuo L, Hokkanen L, Hänninen T, Antikainen R, Bäckman L, Laatikainen T, Paajanen T, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M, Ngandu T. Associations between Prospective and Retrospective Subjective Memory
Complaints and Neuropsychological Performance in Older Adults: The Finger Study. J Int Neuropsychol Soc 2018:24(10):1099-1109.
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53 |
Vermunt L, Veal CD, ter Meulen L, Chrysostomou C, van der Flier W, Frisoni GB, Guessous I, Kivipelto M, Marizzoni M, Martinez-Lage P, Molinuevo JL, Porteous D, Ritchie K, Scheltens P, Ousset P-J, Ritchie CW, Luscan G, Brookes AJ, Visser PJ. European
Prevention of Alzheimer's Dementia Registry: Recruitment and prescreening approach for a longitudinal cohort and prevention trials. Alzheimers Dement 2018:14(6):837-842.
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54 |
Virta LJ, Kälviäinen R, Villikka K, Keränen T. Declining trend in valproate use in Finland among females of childbearing age in 2012-2016 - a nationwide registry-based outpatient study. Eur J Neurol 2018:25(6):869-874.
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55 |
Whelan CD, Altmann A, Botía JA, Jahanshad N, Hibar DP, Absil J, Alhusaini S, Alvim MKM, Auvinen P, ..., Saavalainen T, ..., Kälviäinen R, ..., Sisodiya SM. Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study.
Brain 2018:141(2):391-408.
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