Sisätautien klinikka

Julkaisut 2010
Publications 2010

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1 Aatola H et al. Lifetime risk factors and arterial pulse wave velocity in adulthood: The Cardiovascular Risk in Young Finns Study.
2 Aatola H et al. Lifetime fruit and vegetable consumption and arterial pulse wave velocity in adulthood: The Cardiovascular Risk in Young Finns Study.
3 Ahola TL et al. Positive change in the utilization of antihypertensive and lipid-lowering drugs among adult CHD patients in Finland: results from a large national database between 2000 and 2006.
4 Airaksinen KE et al. How to manage antithrombotic treatment during percutaneous coronary interventions in patients receiving long-term oral anticoagulation: to "bridge" or not to "bridge"? .
5 Airaksinen KEJ et al. Usefulness of outpatient bleeding risk index to predict bleeding complications in patients with long-term oral anticoagulation undergoing coronary stenting .
6 Airas L et al. Central nervous system immune reconstitution inflammatory syndrome (IRIS) after hemapoietic SCT.
7 Alatupa S et al. School performance as a predictor of adulthood obesity: a 21-year follow-up study.
8 Annala A-P et al. Long-term safety of drug-eluting in patients on warfarin treatment .
9 Anttila I et al. Prognostic implications of quantitative ST-segment characteristics and T-wave amplitude for cardiovascular mortality in a general population from the Health 2000 Survey .
10 Arkkila P et al. Diabeetikon käsi- ja nivelmuutokset .
11 Authors/Task Force Members et al. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010) . The task force on the management of grown-up congenital heart disease of the European Society of Cardiology (ESC).
12 Bakris GL et al. Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial .
13 Bengel FM et al. Cardiac neurotransmission imaging: Positron emission tomography .
14 Biancari F et al. Preoperative warfarin treatment and outcome of coronary artery bypass graft surgery.
15 Bry M et al. Vascular endothelial growth factor-B acts as a coronary growth factor in transgenic rats without inducing angiogenesis, vascular leak, or inflammation .
16 Bucci M et al. Intrapericardial, but not extrapericardial, fat is an independent predictor of impaired hyperemic coronary perfusion in coronary artery disease.
17 Böhm M et al. Erectile dysfunction predicts cardiovascular events in high-risk patients receiving telmisartan, rampril, or both: (ONTARGET/TRANSCEND) Trials .
18 Chang SM et al. Efficacy and safety of angiotensin receptor blockade are not mobified by aspirin in patients with chronic heart failure: a cohort study from the Candesartan in Heart failure--Assessment of Reduction in Mortality and morbidity (CHARM) programme .
19 Chumaeva N et al. Early atherosclerosis and cardiac autonomic responses to mental stress: a population-based study of the moderating influence of impaired endothelial function.
20 Chumaeva N et al. Sex differences in the combined effect of chronic stress with impaired vascular endothelium functioning and the development of early atherosclerosis: The Cardiovascular Risk in Young Finns study.
21 Clemons KV et al. Molecular epidemiology of Saccharomyces cerevisiae in an immunocompromised host unit.
22 CURRENT-OASIS 7 investigators et al. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes .
23 Dias J et al. Multimodal approach using oncolytic adenovirus, cetuximab, chemotherapy and radiotherapy in HNSCC low passage tumour cell cultures.
24 Diener H-C et al. Dabigatran compared with warfarin in patients with atrial fibrillation and previous transient ischaemic attack or stroke: a subgroup analysis of the RE-LY trial .
25 Elovainio M et al. Lipid trajectories as predictors of depressive symptoms: The Young Finns Study.
26 Ezekowitz MD et al. Dabigatran and warfarin in vitamin K antagonist-naive and -experienced cohorts with atrial fibrillation .
27 Fagerholm V et al. Assessment of islet specificity of dihydrotetrabenazine radiotracer binding in rat pancreas and human pancreas.
28 Fyhrquist F et al. Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes .
29 Gorin N-C et al. Higher incidence of relapse in patients with acute myelocytic leukemia infused with higher doses of CD34+ cells from leukapheresis products autografted during the first remission .
30 Grénman R, Rönnemaa T. Vuoden 2010 Matti Äyräpään palkinto professori Jorma Viikarille .
31 Gunell M. Salmonella enterica - Mechanisms of Fluoroquinolone and Macrolide Resistance .
32 Gunell M et al. In vitro activity of azithromycin against nontyphoidal Salmonella enterica .
33 Gupta AK et al. Metabolic syndrome, independent of its components, is a risk factor for stroke and death but not for coronary heart disease among hypertensive patients in the ASCOT-BPLA .
34 Hakanen M et al. Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents.
35 Hankey GJ et al. Effect of clopidogrel on the rate and functional severity of stroke among high vascular risk patients .
36 Hannukainen JC et al. Liver and pancreatic fat content and metabolism in healthy monozygotic twins discordant physical activity .
37 Hannukainen JC et al. Higher free fatty acid uptake in visceral than in abdominal subcutaneous fat tissue in men.
38 Harjola V-P et al. The type of acute heart failure and costs of hospitalization .
39 Hawkins NM et al. Baseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programme .
40 Heid IM et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
41 Heinonen I et al. Comparison of exogenous adenosine and voluntary exercise on human skeletal muscle perfusion and perfusion heterogeneity .
42 Heinonen IH et al. Regulation of human skeletal muscle perfusion and its heterogeneity during exercise in moderate hypoxia.
43 Heiskanen M et al. Polymorphism in the IL10 promoter region and early markers of atherosclerosis: The Cardiovascular Risk in Young Finns Study.
44 Hernesniemi JA et al. Interleukin-18 gene polymorphism and markers of subclinical atherosclerosis. The Cardiovascular Risk in Young Finns Study.
45 Hintsanen M et al. A prospective cohort study of deficient maternal nurturing attitudes predicting adulthood work stress independent of adulthood hostility and depressive symptoms.
46 Hirvensalo M et al. Suomalaisten naisten arjessa enemmän askeleita kuin miehillä .
47 Hämäläinen M et al. ETS-related gene ERG expression in AML patients is significantly associated with NPM1 mutation status.
48 Hänninen MR et al. Comparison of home and ambulatory blood pressure measurement in the diagnosis of masked hypertension .
49 Ilva T . Sensitive Troponin Assays: Diagnostic and Prognostic Use in Cardiology .
50 Ilva TJ et al. The etiology and prognostic significance of cardiac troponin I elevation in unselected emergency department patients .
51 Iozzo P et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals .
52 Jalava-Karvinen P et al. Metastasis in the temporal bone mimicking temporal arteritis.
53 Jamula E et al. Safety of uninterrupted anticoagulation in patients requiring elective coronary angiography with or without percutaneous coronary intervention .
54 Johansson JK et al. Factors affecting the variability of home-measured bloof pressure and heart rate: the Finn-home study.
55 Johansson JK et al. Optimal schedule for home blood pressure monitoring based on a clinical approach .
56 Johnsen HE et al. Multiparametric flow cytometry profiling of neoplastic plasma cells in multiple myeloma .
57 Johnsen HE et al. Priming with r-metHuSCF and filgrastim or chemotherapy and filgrastim in patients with malignant lymphomas: a randomized phase II pilot study of mobilization and engraftment.
58 Juonala M et al. Life-time risk factors and progression of carotid atherosclerosis in young adults: the Cardiovascular Risk in Young Finns study .
59 Juonala M et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood . The Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium.
60 Juutilainen A et al. Thoracoabdominal calcifications predict cardiovascular disease mortality in type 2 diabetic and nondiabetic subjects .
61 Kaaja R . Is deep vein thrombosis different during pregnancy? .
62 Kajander S et al. Anatomy and function: PET-CT .
63 Kajander S et al. Cardiac positron emission tomography/computed tomography imaging accurately detects anatomically and functionally significant coronary artery disease.
64 Kallio K et al. Arterial intima-media thickness, endothelial function, and apolipoproteins in adolescents frequently exposed to tobacco smoke.
65 Karjalainen PP et al. Pooled analysis of trials comparing titanium-nitride-oxide-coated stents with paclitaxel-eluting stents in patients undergoing coronary stenting .
66 Karjalainen PP et al. Five-year clinical outcome of titanium-nitride-oxide-coated bioactive stent implantation in a real-world population: A comparison with paclitaxel-eluting: The PORI registry.
67 Karjalainen PP et al. Long-term clinical outcome with titanium-nitride-oxide-coated stents and paclitaxel-eluting stents for coronary revascularization in an unselected population .
68 Karjalainen PP et al. Titanium-nitride-oxide-coated Titan-2 bioactive coronary stent: a new horizon for coronary intervention .
69 Karmi A et al. Increased brain fatty acid uptake in metabolic syndrome .
70 Karstila KL et al. Renal safety of initial combination versus single DMARD therapy in patients with early rheumatoid arthtritis: an 11-year experience from the FIN-RACo Trial .
71 Kauhanen S et al. Clinical PET imaging of insulinoma and beta-cell hyperplasia.
72 Kauppinen-Mäkelin R et al. Increased cancer incidence in acromegaly - a nationwide survey .
73 Kemppainen J et al. Autodiab-tutkimus helpottaa diabeetikon ajokyvyn objektiivista arviontia.
74 Kemppainen J et al. Reversible brain hypometabolism associated with central nervous system systemic lupus erythematosus.
75 Kiechl S et al. Coronary artery disease related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.
76 Kivimäki M et al. Conventional and Mendelian randomization analyses suggest no association between lipoprotein(a) and early atherosclerosis: the young Finns study .
77 Kiviniemi TO et al. Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine.
78 Knip M et al. Prediction of type 1 diabetes in the general population.
79 Knutar O , Järveläinen H . Nuoren miehen "syyläkylvö".
80 Knuuti J , Saraste A . New clinical perspectives from imaging technologies for diagnosis and management of coronary artery disease.
81 Knuuti J , Tuunanen H . Metabolic imaging in myocardial ischemia and heart failure .
82 Koivistoinen T et al. Systemic hemodynamics in young adults with the metabolic syndrome: The Cardiovascular Risk in Young Finns Study .
83 Koivistoinen T et al. Apolipoprotein B is related to arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study.
84 Koivuviita N et al. The effect of revascularization of atherosclerotic renal artery stenosis on coronary flow reserve and peripheral endothelial function .
85 Komar G et al. Decreased blood flow with increased metabolic activity: A novel sign of pancreatic tumor aggressiveness.
86 Korhonen PE et al. The assessment of total cardiovascular risk in hypertensive subjects in primary care .
87 Korkeila P . Venous Thromboembolism and Obstruction After Pacemaker Implantation . A Prospective Study of 150 Consecutive Cardiac Pacing Device Implantations .
88 Korkeila P et al. Clinical and laboratory risk factors of thrombotic complications after pacemaker implantation: a prospective study.
89 Koskenvuo JW, Kantola IM. Evaluating enzyme replacement therapy in Fabry diease .
90 Koskenvuo JW et al. Cardiopulmonary involvement in Fabry´s disease.
91 Koskinen J et al. Arterial structure and function after recovery from the metabolic syndrome: The Cardiovascular Risk in Young Finns Study .
92 Koskivirta I et al. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.
93 Kotilainen P et al. Verisuonikatetreihin liittyvät infektiot.
94 Kudomi N et al. Extraction of input function from rat [18F]FDG PET images .
95 Laaksonen M et al. Determinants of bone strength and fracture incidence in adult Finns: Cardiovascular Risk in Young Finns Study (the GENDI pQCT study).
96 Lakkisto P et al. Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alfa, SDF-1alfa and VEGF-B .
97 Lammintausta A et al. Myocardial infraction events and cardiovascular risk factor levels in Finnish- and Swedish-speaking populations in Finland.
98 Lango Allen H et al. Hundreds of variants clustered in genomic loci and biological pathways affect human height.
99 Lassus JPE et al. Markers of renal function and acute kidney injury in acute heart failure: definitions and impact on outcomes of the cardiorenal syndrome.
100 Lehtopolku M et al. Antimicrobial susceptibilities of multidrug-resistant Campylobacter jenuni and C. coli strains: in vitro activities of 20 antimicrobial agents .
101 Leino K.A. et al. Spread of spinal block in patients with rheumatoid arthritis.
102 Leino KA et al. The effect of desmopressin on blood loss in patients with rheumatoid arthritis undergoing hip arthroplasty.
103 Leino P, Rönnemaa T. Vain osa glukoosin omaseurantamittareista sopii ammattikäyttöön.
104 Leinonen V-M et al. Low-dose acetylsalicylic acid and blood pressure control in drug-treated hypertensive patients .
105 Lindgren P et al. The economic consequences of non-adherence to lipid-lowering therapy: results from the Anglo-Scandinavian-Cardiac Outcomes Trial .
106 Linko R et al. One-year mortality, quality of life and predicted life-time cost-utility in critically ill patients with acute respiratory failure .
107 Lip GYH et al. Antithrombotic management of atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing coronary stenting: executive summary - a concensus document of the European society of cardiology working group on thrombosis. Endorsed by the European heart rhythm association (EHRA) and the European association of percutaneous cardiovascular interventions (EAPCI).
108 Lip GYH et al. Management of antithrombotic therapy in atrial fibrillation patients presenting with acute coronary syndrome and/or undergoing percutaneous coronary intervention/stenting .
109 Lund J et al. Free vs total pregnancy-associated plasma protein A (PAPP-A) as a predictor of 1-year outcome in patients presenting with non-ST elevation acute coronary syndrome .
110 Lyytikäinen O et al. Koagulaasinegatiiviset stafylokokit .
111 Lyytikäinen O et al. Infektioepidemioiden selvittely ja hallinta .
112 Magnussen CG et al. Pediatric metabolic syndrome predicts adulthood metabolic syndrome, subclinical atherosclerosis, and type 2 diabetes mellitus but is no better than body mass index alone: the Bogalusa Heart Study and the Cardiovascular Risk in Young Finns Study.
113 Malmberg M et al. Cardiomyocyte apoptosis after cardioplegic ischemia: Comparison to unprotected regional ischemia-reperfusion.
114 Mattsson N et al. Metabolic syndrome and carotid intima-media thickness in young adults: Roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: The Cardiovascular Risk in Young Finns Study .
115 Mehta A et al. Fabry disease: a review of current management strategies .
116 Michallet M et al. The impact of HLA matching on long-term transplant outcome after allogeneic hematopoietic stem cell transplantation for CLL: a retrospective study from the EBMT registry.
117 Mielniczuk LM et al. The relationship between right ventricular function and increased right ventricular [18F] fluorodeoxyglucose accumulation in patients with heart failure .
118 Miettinen J et al. Effects of intracoronary infusion of bone marrow-derived stem cells on pulmonary artery pressure and diastolic function after myocardial infarction .
119 Miettinen JA et al. Effects of intracoronary injection of autologous bone marrow-derived stem cells on natriuretic peptides and inflammatory markers in patients with acute ST-elevation myocardial infraction .
120 Miettinen JA et al. Determinants of functional recovery after myocardial infarction of patients treated bone marrow-derived stem cells after thrombolytic therapy .
121 Miettinen TA et al. Relation of non-cholesterol sterols to coronary risk factors and carotid intima-media thickness: The Cardiovascular Risk in Young Finns Study.
122 Möttönen T et al. Nivelreuman varhainen diagnoosi ja hoito - tavoitteena remissio .
123 Nekolla S, Saraste A. PET and MRI in Cardiac Imaging.
124 Niiranen TJ et al. Home-measured blood pressure is a stronger predictor of cardiovascular risk than office blood pressure . The Finn-home study .
125 Okser S et al. Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: The Cardiovascular Risk in Young Finns Study.
126 Oksi J et al. Borreliat, treponeemat ja leptospirat .
127 Pahkala K et al. Clustered metabolic risk and leisure-time physical activity in adolescents: effect of dose?
128 Pakarinen M et al. Secular trend in the menopausal age Finland 1997-2007 and correlation with socioeconomic, reproductive and lifestyle factors .
129 Palojoki E et al. Pregnancy and childbirth in carriers of the lamin A/C-gene mutation .
130 Poikonen E et al. Secular trend in candidemia and the use of fluconazole in Finland, 2004-2007 .
131 Putkonen M et al. Depth of response assessed by quantitative ASO-PCR predicts the outcome after stem cell transplantation in multiple myeloma.
132 Päivä H et al. Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study.
133 Raiko JRH et al. Cardiovascular risk scores in the prediction of subclinical atherosclerosis in young adults: evidence from the cardiovascular risk in a young Finns study.
134 Raiko JRH et al. Tracking of noninvasive ultrasound measurements of subclinical atherosclerosis in adulthood: findings from the Cardiovascular Risk in Young Finns study.
135 Raiko JRH et al. Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: Levels and 6-year changes in risk factors.
136 Rantalaiho V et al. Early combination disease-modifying antirheumatic drug therapy and tight disease control improve long-term radiologic outcome in patients with early rheumatoid arthritis:the 11-year results of the Finnish Rheumatoid Arthritis Combination Therapy trial.
137 Rantanen I, Tuominen R. Relative magnitude of presenteeism and work-related factors affecting them among health care professionals .
138 Rothwell PM et al. Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke .
139 Rubboli A et al. Bleeding after coronary stenting in patients on oral anticoagulation: who is guilty?
140 Ruotsalainen E et al. Changes in cytokine levels during acute hyperinsulinemia in offspring of type 2 diabetic subjects .
141 Ruottinen S et al. Dietary fiber does not displace energy but is associated with decreased serum cholesterol concentrations in healthy children 1-3.
142 Saarikoski LA et al. Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults-The Cardiovascular Risk in Young Finns Study.
143 Saglio G et al. Nilotinib versus imatinib for newly diagnosed chronic myeloid leukemia .
144 Sainio A et al. Hyperglycemic conditions modulate connective tissue reorganization by human vascular smooth muscle cells through stimulation of hyaluronan synthesis .
145 Saraste A et al. Integrated anatomy and viability assessment PET-CT.
146 Saraste A et al. Congestive heart failure .
147 Saraste A et al. PET innervation and receptors .
148 Shiri R et al. Incidence of nonspesific and radiating low back pain: Followup of 24-39-year-old adults of the Young Finns Study.
149 Sivenius J et al. Aivohalvausten ilmaantuvuuden kehityssuunnat Suomen väestössä vuoteen 2030.
150 Skilton MR et al. Childbearing, child-rearing, cardiovascular risk factors, and progression of carotid intima-media thickness: The Cardiovascular Risk in Young Finns Study.
151 Smith EN et al. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa Heart Study.
152 Speliotes EK et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
153 Stein A et al. Local erythropoietin and endothelial progenitor cells improve regional cardiac function in acute myocardial infarction.
154 Sundell J . Turvonneen jalan arvoitus .
155 Sutinen J et al. Skeletal muscle mitochondrial DNA content and aerobic metabolism in patients with antiretroviral therapy-associated lipoatrophy.
156 Syrjälä H et al. Blood stream infections during chemotherapy-induced neutropenia in adult patients with acute myeloid leukemia: treatment cycle matters .
157 Taittonen M et al. Selkäydinstimulaatio refraktorisen rasitusrintakivun hoidossa.
158 Tertti K et al. The role of organic cation transporters (OTCs) in the transfer of methormin in the dually perfused human placenta.
159 Teräs M et al. Dual-gated cardiac PET - Clinical feasibility study.
160 Toivonen R et al. Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart .
161 Laaksonen M et al. Lactase gene C/T -13910 polymorphism, calcium intake, and pQCT bone traits in Finnish adults .
162 Tolvanen T et al. Biodistribution and radiation dosimetry of [11C]choline: a comparison between rat and human data .
163 Tuomela J et al. Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.
164 Tuominen R et al. Relative importance of the functional abilities comprising Health Assessment Questionnaire Disability Index among rheumatoid arthritis patients .
165 Tuominen R et al. Perceived functional disabilities among rheumatoid arthritis patients .
166 Vahtola E et al. Sirtuin1-p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat.
167 Valtonen P et al. ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study.
168 Varis J , Kantola I . The choice of home bood pressure result reporting method is essential: Results mailed to physicians did not improve hypertension control compared with ordinary office-based blood pressure treatment .
169 Varis J et al. Cholesterol microembolization syndrome: a complication of anticoagulant therapy.
170 Varpula T et al. Äkillisen hengitysvajauksen esiintyvyys, hoito ja ennuste Suomessa -FINNALI-tukimus .
171 Vepsäläinen T et al. Proteinuria modifies the effects of physical activity on total and cardiovascular disease mortality rates in patients with type 2 diabetes .
172 Viikari J. Lasten ja nuorten aikuisten ateroskleroosin riskitekijät ja elintapamuutokset .
173 Virkki LM et al. Biological therapy for psoriatic arthritis in clinical practice: Outcomes up to 2 years .
174 Virtanen L et al. Tromboosiprofylaksi suomalaisessa sairaalahoidossa .
175 Vuopio-Varkila J et al. A-ryhmän streptokokki.
176 Vuopio-Varkila J et al. Staphylococcus aureus.
177 Wallentin L et al. Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial .
178 Wallentin L et al. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial .
179 Weber MA et al. Cardiovascular events during differing hypertension therapies in patients with diabetes .
180 Widén E et al. Distinct variants at LIN28B. Influence growth in height from birth to adulthood .
181 Wittfooth S et al. Studies on the effects of heparin products on pregnancy-associated plasma protein A.
182 Würtz P et al. Characterization of systemic metabolic phenotypes associated with subclinical atherosclerosis.
183 Yang X et al. Leadership component of type a behavior predicts physical activity in early midlife .
184 Yang X et al. Sustained involvement in youth sports activities predicts reduced chronic job strain in early midlife.
185 Yrjänäinen H et al. Persistence of borrelial DNA in the joints of Borrelia burgdorferi-infected mice after ceftriaxone treatment .
Julkaisutietokanta 24.8.2011 Publications Data Base 24.8.2011