Kliinisen farmakologian yks.

Julkaisut 2010
Publications 2010

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1 Alakurtti K et al. Reproducibility of striatal and thalamic dopamine D2 receptor binding using (11C)raclopride with high-resolution positron emission tomography.
2 Crassous PA et al. Identification of a novel 12-nucleotide insertion polymorphism in the promoter region of ADRA2B: full linkage with the 9-nucleotide deletion in the coding region and influence on transcriptional activity.
3 Grönholm-Nyman P et al. Learning and forgetting new names and objects in MCI and AD.
4 Grönlund J et al. Effect of telithromycin on the pharmacokinetics and pharmacodynamics of oral oxycodone.
5 Grönlund J et al. Exposure to oral oxycodone in increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone.
6 Grönlund J et al. Effect of inhibition of cytochrome P450 enzymes 2D6 and 3A4 on the pharmacokinetics of intravenous oxycodone: A randomized, three-phase, crossover, placebo-controlled study.
7 Grönlund J et al. Miconazole oral gel increases the exposure to oral oxycodone by inhibition of CYP2D6 and CYP3A4.
8 Hagelberg NM et al. Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S-ketamine.
9 Haltia LT et al. Acute hormonal changes following intravenous glucose challenge in lean and obese human subjects.
10 Hannukainen JC et al. Liver and pancreatic fat content and metabolism in healthy monozygotic twins discordant physical activity .
11 Helin-Salmivaara A et al. Pattern of statin use among 10 cohorts of new users from 1995 to 2004: A Register-Based Nationwide Study.
12 Hellsten KS et al. Human locus coeruleus neurons express the GABA A receptor gamma2 subunit gene and produce benzodiazepine binding.
13 Hilli J et al. NCT01110291: induction of CYP3A activity and lowered exposure to docetaxel in patients with primary breast cancer.
14 Hirvonen J et al. Human biodistribution and radiation dosimetry of (11)C-(R)-PK11195, the prototypic PET ligand to image inflammation.
15 Hirvonen MM et al. COMT Val158Met genotype doe not alter cortical or striatal dopaminen D2 receptor availability in vivo.
16 Iirola T et al. Highly variable pharmacokinetics of dexmedetomidine during intensive care: a case report.
17 Jokinen P et al. [(11)C]PIB-, [(18)F]FDG-PET and MRI imaging in patients with Parkinson's disease with and without dementia.
18 Järvelä JT et al. Kainic acid-induced neurodegeneration and activation of inflammatory processes in organotypic hippocampal slice cultures: Treatment with cyclooxygenase-2 inhibitor does not prevent neuronal death.
19 Karvonen MK et al. Ropinirole diminishes myoclonus and improves writing and postural balance in an ULD patient.
20 Kohli U et al. Effects of variation in the human alpha2- and alpha2C-adrenoceptor genes on cognitive tasks and pain perception.
21 Kopp UC et al. Dietary sodium modulates the interaction between efferent and afferent renal nerve activity by altering activation of (alpha)2-adrenocpetors on renal sensory nerves.
22 Kuoppamäki M et al. Night-time bioavailability of levodopa/carbidopa/entacapone is higher compared to controlled-release levodopa/carbidopa.
23 Lampela P et al. Effects of medication assessment as part of a comprehensive geriatric assessment on drug use over a 1-year period. A population-based intervention study.
24 Lee MS et al. The effect of age on motor deficits and cerebral glucose metabolism of Parkinson's disease.
25 Lind U et al. Octopamine receptors from the barnacle balanus improvisus are activated by the alpha2-adrenoceptor agonist medetomidine.
26 Lumme V et al. Cortical dopamine D2/D3 receptors and verbal memory in man.
27 Lyoo CH et al. Cerebral glucose metabolism of Parkinson's disease patients with mild cognitive impairment.
28 Mosconi L et al. Increased fibrillar amyloid-B burden in normal individuals with a family history of late-onset Alzheimer's.
29 Nieminen T. The Role of Cytochrome P450 3A Inducers and Inhibitors in the Metabolism and the Effects of Oxycodone.
30 Nieminen TH et al. St John`s wort greatly reduces the concentrations of oral oxycodone.
31 Nieminen TH et al. Grapefruit juice enhances the exposure to oral oxycodone.
32 Nieminen TH et al. Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir .
33 Nordberg A et al. The use of PET in Alzheimer disease.
34 Någren K et al. Radiopharmaceuticals for positron emission tomography investigations of Alzheimer's disease.
35 Paimela T et al. Influence of selective estrogen receptor modulators on interleukin-6 expression in human retinal pigment epithelial cells (ARPE-19).
36 Posti JP et al. Dorsal hand vein responses to the a(1)-adrenoceptor agonist phenylephrine do not predict responses to the a(2)-adrenoceptor agonist dexmedetomidine.
37 Rinne JO et al. 11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.
38 Rinne JO, Någren K. Positron emission tomography in at risk patients and in the progression of mild cognitive impairment to Alzheimer's disease.
39 Rissanen E et al. Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET).
40 Rozwandowicz-Jansen A et al. Homogeneous GTP binding assay employing QRET technoloby.
41 Ruokoniemi P et al. Statin adherence and the risk of major coronary events in patients with diabetes: A nested Ccse-control study.
42 Saari TI et al. Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone.
43 Saarikoski LA et al. Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults-The Cardiovascular Risk in Young Finns Study.
44 Saczewski F et al. 3-[(Imidazolidin-2-yl)imino]indazole ligands with selectivity for the a(2)-adrenoceptor compared to the imidazoline I(1) receptor.
45 Suotunen T et al. Visual assessment of (11C)PIB PET in patients with cognitive impairment.
46 Tertti K et al. The role of organic cation transporters (OTCs) in the transfer of methormin in the dually perfused human placenta.
47 Tirkkonen T. Epidemiology of Cytochrome P450-mediated Drug-Drug Interactions.
48 Tirkkonen T et al. Potential CYP2C9-mediated drug-drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide.
49 Virta JJ et al. Midlife alcohol consumption and later risk of cognitive impairment: a twin follow-up study.
50 Yamamoto K et al. Two tyrosine hydroxylase genes in vertebrates - New dopaminergic territories revealed in the zebrafish brain.
51 Young S et al. Antinociceptive synergian of MD-354 and clonidine. Part II. The alpha-adrenoceptor component.
Julkaisutietokanta 24.8.2011 Publications Data Base 24.8.2011