Neurologian yksikkö
Department of Neurology

Julkaisut 2012
Publications 2012

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1 Blasiak J, Synowiec E, Salminen A, Kaarniranta K. Genetic variability in DNA repair proteins in age-related macular degeneration. Int J Mol Sci 2012(13):13378-13397.
2 Coric C, van Dyck CH, Salloway S..., Soininen H, Thein S, ..., Berman RM. Safety and tolerability of the gamma-secretase inhibitor avagacestat in a phase 2 study of mild to moderate Alzheimer Disease. Arch Neurol 2012:69(11):1430-1440.
3 Greco I, Day N, Riddoch-Contreras J, Reed J, Soininen H, ..., Lovestone S. Alzheimer's disease biomarker discovery using in silico literature mining and clinical validation. J Transl Med 2012:10(1):217.
4 Hallikainen I, Koivisto AM, Paajanen T, Hiltunen A, Karppi P, Vanhanen M, Välimäki T, Herukka S-K, Soininen H, Hänninen T. Cognitive and neuropsychiatric symptom differences in early stages of Alzheimer's Disease: Kuopio ALSOVA Study. Dement Geriatr Cogn Disord 2012:2:209-218.
5 Hankey GJ, Patel MR, ..., Hacke W, For The ROCKET AF Steering Committee and Investigators, Jäkälä P. Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol 2012:11:315-322.
6 Hartikainen P, Räsänen J, Julkunen V, Niskanen E, Hallikainen M, Kivipelto M, Vanninen R, Remes AM, Soininen H. Cortical thickness in frontotemporal dementia, mild cognitive impairment, and Alzheimer's Disease. J Alzheimer Dis 2012:30:857-874.
7 Huumonen K, Immonen H-K, Baverstock K, Hiltunen M, Korkalainen M, Lahtinen T, Parviainen J, Viluksela M, Wong G, Naarala J, Juutilainen J. Radiation-induced genomic instability in Caenorhabditis elegans. Mutat Res 2012:748:36-41.
8 Jesse S, Lehnert S, Jahn O, Parnetti L, Soininen H, Herukka S-K, Steinacker P, ..., Otto M. Differential sialylation of serpin A1 in the early diagnosis of Parkinson's disease dementia. PLoS ONE 2012:7(11):e48783.
9 Kaarniranta K, Kauppinen A, Blasiak J, Salminen A. Autophagy regulating kinases as potential therapeutic targets for age-related macular degeneration. Future Med Chem 2012:4(17):2153-2161.
10 Kaarniranta K, Paananen J, Nevalainen T, Sorri I, Seitsonen S, Immonen I, Salminen A, Pulkkinen L, Uusitupa M. Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population. Neurosci Lett 2012:513:233-237.
11 Kauppinen A, Niskanen H, SuuronenT, Kinnunen K, Salminen A, Kaarniranta K. Oxidative stress activates NLRP3 inflammasomes in ARPE-19 cells-Implications for age-related macular degeneration (AMD). Immunol Lett 2012:147(1-2):29-33.
12 Kivipelto M, Ngandu T, Soininen H, Laatikainen T. Voiko muistisairauksia ehkäistä? Kirjassa: Reivinen J, Vähäkylä L, toim. Kansan tervys, yksilön hyvinvointi, s. 91-107. Helsinki: Gaudeamus Oy, 2012.
13 Koskenkorva P, Niskanen E, Hyppönen J, Könönen M, Mervaala E, Soininen H, Kälviäinen R, Vanninen R. Sensorimotor, visual, and auditory cortical atrophy in Unverricht-Lundborg Disease mapped with cortical thickness analysis. AJNR Am J Neuroradiol 2012:33:878-883.
14 Kälviäinen R, Dörfler A. Structural brain imaging. Handb Clin Neurol 2012:107:359-368.
15 Könönen M, Tarkka IM, Niskanen E, Pihlajamäki M, Mervaala E, Pitkänen K, Vanninen R. Functional MRI and motor behavioral changes obtained with constraint-induced movement therapy in chronic stroke. Eur J Neurol 2012:19(4):578-586.
16 Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von und zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne J, Savolainen S. Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus. Neurodegenerative Dis 2012:10:166-169.
17 Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. Post-mortem findings in 10 patients with presumed normal-pressure hydrocephalus and review of the literature. Neuropathol Appl Neurobiol 2012:38:72-86.
18 Liu Y, Julkunen V, Paajanen T, Westman E, Wahlund L-O, Aitken A, Sobow T, Mecocci P, Tsolaki M, Vellas B, Muehlboeck S, Spenger C, Lovestone S, Simmons A, Soininen H, AddNeuroMed Consortium. Education increases reserve against Alzheimer's disease - evidence from structural MRI analysis. Neuroradiology 2012:54:929-938.
19 Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, Simmons A, Lovestone S, Dobson R, Hodges A. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's Disease blood. J Alzheimer Dis 2012:30:685-710.
20 Mattila J, Soininen H, Koikkalainen J, Rueckert D, Wolz R, Waldemar G, Lötjönen J. Optimizing the diagnosis of early Alzheimer's Disease in mild cognitive impairment subjects. J Alzheimer Dis 2012:32:969-979.
21 Morrow DA, Braunwald E, ..., Murphy SA, For The TRA 2P-TIMI 50 Steering Committee and Investigators, Jäkälä P. Vorapaxar in the secondary prevention of atherothrombotic events. N Engl J Med 2012:366:1404-1413.
22 Munoz-Ruiz MA, Hartikainen P, Koikkalainen J, Wolz R, Julkunen V, Niskanen E, Herukka S-K, Kivipelto M, Vanninen R, Rueckert D, Liu Y, Lötjönen J, Soininen H. Structural MRI in frontotemporal dementia: Comparisons between hippocampal volumetry, tensor-based morphometry and voxel-based morphometry. PLoS ONE 2012:7(12):e52531.
23 Paimela T, Ryhänen T, Kauppinen A, Marttila, Salminen A, Kaarniranta K. The preservative polyquaternium-1 increases cytoxicity and NF-kappaB linked inflammation in human corneal epithelial cells. Mol Vis 2012:18:1189-1196.
24 Pihlajamäki M, Soininen H. Alzheimer's Disease. In: Bartsch T, ed. The clinical neurobiology of the hippocampus, p. 224-244. Englanti: Oxford University Press, 2012.
25 Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JAA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. APOE4 predicts amyloid-beeta in cortical brain biopsy but not idiopathic normal pressure hydrocephalus. J Neurol Neurosurg Psychiatry 2012:83:1119-1124.
26 Salminen A, Hyttinen JMT, Kauppinen A, Kaarniranta K. Context-dependent regulation of autophagy by IKK-NF-kappaB signaling: Impact on the aging process. Int J Cell Biol 2012:Article ID 849541,15 pages.
27 Salminen A, Kaarniranta K. AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network. Ageing Res Rev 2012:11:230-241.
28 Salminen A, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H, Alafuzoff I. Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease. Prog Neurobiol 2012:96(1):87-95.
29 Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: disturbed interplay between autoghagy and inflammasomes. Aging (Albany NY) 2012:4(3):166-175.
30 Salminen A, Kauppinen A, Kaarniranta K. Phytochemicals suppress nuclear factor-kappaB signaling: impact on health span and the aging process. Curr Opin Clin Nutr Metab Care 2012:15(1):23-28.
31 Salminen A, Kauppinen A, Kaarniranta K. Emerging role of NF-kappaB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 2012:24:835-845.
32 Salminen A, Ojala J, Kaarniranta K, Kauppinen A. Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases. Cell Mol Life Sci 2012:69:2999-3013.
33 Sarajärvi T, Lipsanen A, Mäkinen P, Peräniemi S, Soininen H, Haapasalo A, Jolkkonen J, Hiltunen M. Bepridil decreases A beta and calcium levels in the thalamus after middle cerebral artery occlusion in rats. J Cell Mol Med 2012:16(11):2754-2767.
34 Seppälä TT, Nerg O, Koivisto AM, Rummukainen J, Puli L, Zetterberg H, Pyykkö OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings. Neurology 2012:78:1568-1575.
35 Simonsen AH, Mattila J, Hejl A-M, Frederiksen KS, Herukka S-K, Hallikainen M, van Gils M, Lötjönen J, Soininen H, Waldemar G. Application of the PredictAD software tool to predict progression in patients with mild cognitive impairment. Dement Geriatr Cogn Disord 2012:34:344-350.
36 Spulber G. Imaging the Progression from Mild Cognitive Impairment to Alzheimer's Disease. Doctoral dissertation. Kuopio: 2012. Publications of the University of Eastern Finland. Dissertations in Health Sciences 104. 57 p., append.
37 Suoranta S, Manninen H, Koskenkorva P, Könönen M, Laitinen R, Lehesjoki A-E, Kälviäinen R, Vanninen R. Thickened skull, scoliosis and other skeletal findings in Unverricht-Lundborg disease link cystatin B function to bone metabolism. Bone 2012:51(6):1016-1024.
38 Sutinen EM, Pirttilä T, Anderson G, Salminen A, Ojala JO. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-beta production in human neuron-like cells. J Neuroinflammation 2012:9:199.
39 Tolppanen A-M, Solomon A, Soininen H, Kivipelto M. Midlife vascular risk factors and Alzheimer's Disease: Evidence from epidemiological studies. J Alzheimer Dis 2012:32:531-540.
40 Tukiainen T, Jylänki P, Mäkinen V-P, Gröhn O, Hallikainen M, Soininen H, Kivipelto M, Kaski K, Groop PH, Savolainen MJ, Pirttilä T, Soininen P, Ala-korpela M. Mild cognitive impairment associates with concurrent decreases in serum cholesterol and cholesterol-related lipoprotein subclasses. J Nutr Health Aging 2012:16(7):631-635.
41 Välimäki T, Vehviläinen-Julkunen K, Pietilä A-M, Koivisto A. Life orientation in Finnish family caregivers' of persons with Alzheimer's disease: A diary study. Nurs Health Sci 2012:14:480-487.
42 Zetterberg H, Lunn MP, Herukka SK. Clinical use of cerebrospinal fluid biomarkers in Alzheimer's disease. Biomark Med 2012:6(4):371-376.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 19.8.2022 Publications Data Base 19.8.2022