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Aguilar C, Westman E, Muehlboeck J-S, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Lovestone S, Spenger C, Simmons A, Wahlund L-O. Different multivariate techniques for automated classification of MRI data in Alzheimer?s disease and mild
cognitive impairment. Psychiatry Res 2013:212(2):89-98.
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Antila K, Lötjönen J, Thurfjell L, ..., Soininen H. The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease. Interface Focus 2013:3(2):20120072.
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Blasiak J, Salminen A, Kaarniranta K. Potential of epigenetic mechanisms in AMD pathology. Front Biosci (Schol Ed) 2013(5):412-425.
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Clerx L, van Rossum IA, ..., Soininen H, Visser PJ. Measurements of medial temporal lobe atrophy for prediction of Alzheimer?s disease in subjects with mild cognitive impairment. Neurobiol Aging 2013:34(8):2003-2013.
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Damian M, Hausner L, Jekel K, Richter M, Froelich L, Almkvist O, Boada M, Bullock R, De Deyn PP, Frisoni GB, Hampel H, Jones RW, Kehoe P, Lenoir H, Minthon L, Olde Rikkert MG, Rodriguez G, Scheltens P, Soininen H, Spiru L, Touchon J, Tsolaki M,
Vellas B, Verhey FR, Winblad B, Wahlund LO, Wilcock G, Visser PJ. Single-domain amnestic mild cognitive impairment idenfied by cluster analysis predicts Alzheimer?s Disease in the European Prospective DESCRIPA Study. Dement Geriatr Cogn Disord
2013:36(1-2):1-19.
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Danner N, Julkunen P, Hyppönen J, Niskanen E, Säisänen L, Könönen M, Koskenkorva P, Vanninen R, Kälviäinen R, Mervaala E. Alterations of motor cortical excitability and anatomy in Unverricht-Lundborg disease. Mov Disord
2013:28(13):1860-1867.
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Elias-Sonnenschein LS, Helisalmi S, ..., Remes AM, Koivisto AM, Mattila KM, Lehtimäki T, Verhey FRJ, Visser PJ, Soininen H, Hiltunen M. Genetic loci associated with Alzheimer?s Disease and cerebrospinal fluid biomarkers in a Finnish case-control
cohort. PLoS ONE 2013:8(4):e59676.
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Glauser T, Ben-Menachem E, ..., Kälviäinen R, ..., Tomson T. Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes. Epilepsia (NY) 2013:54(3):551-563.
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Guerreiro R, Wojtas A, Bras J, Carrasquillo M, ..., Alzheimer Genetic Analysis Group, Soininen H. TREM2 variants in Alzheimer's disease. N Engl J Med 2013:368(2):117-127.
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Hallikainen I, Hänninen T, Fraunberg M, Hongisto K, Välimäki T, Hiltunen A, Karppi P, Sivenius J, Soininen H, Koivisto A. Progression of Alzheimer's disease during a three-year follow-up using the CERAD-NB total score: Kuopio ALSOVA study. Int
Psychogeriatr 2013:25(8):1335-1344.
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Hiltunen M, Haapasalo A, Soininen H. Alzheimerin taudin uudet riskigeenit - tautia ennakoivat biomarkkerit? Duodecim 2013:129(6):583-588.
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Hyttinen JMT, Niittykoski M, Salminen A, Kaarniranta K. Maturation of autophagosomes and endosomes: A key role for Rab7. Biochim Biophys Acta 2013:1833(3):503-510.
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Iqbal K, Flory M, Soininen H. Clinical symptoms and symptom signatures of Alzheimer's disease subgroups. J Alzheimers Dis 2013:37(3):475-481.
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Jolkkonen J, Ortega FJ, Jäkälä P. Itä-Suomen yliopisto tutkii kuntoutumisen tehostamista lääkehoidolla.
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Julkunen P, Säisänen L, Könönen M, Vanninen R, Kälviäinen R, Mervaala E. TMS-EEG reveals impaired intracortical interactions and coherence in Unverricht-Lundborg type progressive myoclonus epilepsy (EPM1). Epilepsy Res
2013:106(1-2):103-112.
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Kaarniranta K, Sinha D, Blasiak J, Kauppinen A, Veréb Z, Salminen A, Boulton ME, Petrovski G. Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration.
Autophagy 2013:9(7):1-12.
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Kasperaviciute D, Catarino CB, Matarin M, ..., Kälviäinen R, ..., Kantanen AM, ..., Sisodiya SM. Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A. Brain 2013:136(10):3140-3150.
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Kauppinen A, Salminen A, Kaarniranta K. Inflammation as a target of minocycline: special interest in the regulation of inflammasome signaling. Inflammasome 2013:1:2-14.
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Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. Antagonistic crosstalk between NF-kB and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal 2013:25(10):1939-1948.
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Keränen T, Kälviäinen R, Rantala H. Uusimmat epilepsialääkkeet. Suomen Lääkärilehti 2013:68(33):1980-1984.
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Kivipelto M, Solomon A, ..., Strandberg T, Tuomilehto J, Soininen H. The Finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimers Dement 2013:9(6):657-665.
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Klettner A, Kauppinen A, Blasiak J, Roider J, Salminen A, Kaarniranta K. Cellular and molecular mechanisms of age-related macular degeneration: From impaired autophagy to neovascularization. Int J Biochem Cell Biol 2013:45(7):1457-1467.
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Kämäläinen A, Viswanathan J, Natunen T, ..., Soininen H, Herukka SK, Hiltunen M. GRN variant rs5848 reduces plasma and brain levels of granulin in Alzheimer?s disease patients. J Alzheimers Dis 2013:33(1):23-27.
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Lambert J-C, Grenier-Boley B, ...., Soininen H, ...., Williams J, Amouyel P. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer?s disease. Mol Psychiatry 2013:18(4):461-470.
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Lambert JC, Ibrahim-Verbaas CA, ..., Soininen H, ..., Amouyel P. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013:45(2):1452-1458.
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Leinonen V, Rinne JO, Virtanen KA, Eskola O, Rummukainen J, Huttunen J, von und zu Fraunberg M , Nerg O, Koivisto AM, Rinne J, Jääskeläinen JE, ..., Grachev ID. Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of
cerebral cortical amyloid in normal pressure hydrocephalus patients. Eur J Neurol 2013:20(7):1043-1052.
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Leung R, Proitsi P, Simmons A, Lunnon K, ..., Soininen H, Wahlund L-O, Lovestone S. Inflammatory proteins in plasma are associated with severity of Alzheimer's disease. PLoS ONE 2013:8(6):e64971.
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Liu Y, Mattila J, ..., Herukka SK, Waldemar G, Lötjönen J, Soininen H. Predicting AD conversion: comparison between prodromal AD guidelines and computer assisted predictAD tool. PLoS ONE 2013:8(2):e55246.
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Lunnon K, Sattlecker M, ..., Soininen H, ..., Lovestone S, Dobson R, Hodges A. A blood gene expression marker of early Alzheimer?s disease. J Alzheimers Dis 2013:33(3):737-753.
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Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, Soininen H, Laatikainen T, Mecocci P, Kivipelto M. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp
Gerontol 2013:48:1428-1435.
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Mangialasche F, Westman E, Kivipelto M, Muehlboeck J-S, Cecchetti R, Baglioni M, Tarducci R, Gobbi G, Floridi P, Soininen H, Kloszewska I, Tsolaki M, Vellas B, Spenger C, Lovestone S, Wahlund L-O, Simmons A, Mecocci P. Classification and prediction
of clinical diagnosis of Alzheimer?s disease based on MRI and plasma measures of a-/y-tocotrienols and y-tocopherol. J Intern Med 2013:273(6):602-621.
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Manninen O, Koskenkorva P, Lehtimäki KK, Hyppönen J, Könönen M, Laitinen T, Kalimo H, Kopra O, Kälviäinen R, Gröhn O, Lehesjoki AE, Vanninen R. White matter degeneration with Unverricht-Lundborg progressive myoclonus epilepsy: A translational
diffusion-tensor imaging study in patients and cystatin B-deficient mice. Radiology 2013:269(1):232-239.
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Martiskainen H, Haapasalo A, Kurkinen KM, Pihlajamäki J, Soininen H, Hiltunen M. Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease. Expert Opin Ther Targets 2013:17(7):781-794.
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Munoz-Ruiz MA, Hartikainen P, Hall A, Mattila J, Koikkalainen J, Herukka SK, Julkunen V, Vanninen R, Liu Y, Lötjönen J, Soininen H. Disease state fingerprint in frontotemporal degeneration with reference to Alzheimer?s Disease and mild cognitive
impairment. J Alzheimers Dis 2013:35(4):727-739.
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Natunen T, Martiskainen H, Sarajärvi T, Helisalmi S, Pursiheimo J-P, Viswanathan J, Laitinen M, Mäkinen P, Kauppinen T, Rauramaa T, Leinonen V, Alafuzoff I, Haapasalo A, Soininen H, Hiltunen M. Effects of NR1H3 genetic variation on the expression of
liver X receptor alfa and the progression of Alzheimer's disease. PLoS ONE 2013:8(11):e80700.
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Natunen T, Parrado AR, Helisalmi S, Pursiheimo JP, ..., Soininen H, Tanzi RE, Hiltunen M. Elucidation of the BACE1 regulating factor GGA3 in Alzheimer's disease. J Alzheimers Dis 2013:37(1):217-232.
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Nho K, Corneveaux JJ, Kim S, ..., Soininen H, ..., Saykin AJ. Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment. Mol Psychiatry
2013:18(7):781-787.
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Nho K, Corneveaux JJ, Kim S, Lin H, ..., Soininen H, ..., Saykin AJ. Identification of functional variants from whole-exome sequencing, combined with neuroimaging genetics. Mol Psychiatry 2013:18(7):739.
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Peltonen HM, Haapasalo A, Hiltunen M, Kataja V, Kosma VM, Mannermaa A. Gamma-secretase components as predictors of breast cancer outcome. PLoS ONE 2013:8(11):e79249, 13 p.
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Ramakers IH, Verhey FR, Scheltens P, Hampel H, Soininen H, Aalten P... Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment. Psychol Med 2013:43(5):911-920.
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Rubio-Moscardo F, Setó-Salvia N, Pera M, ..., Soininen H, ... Rare variants in calcium homeostasis modulator 1 (CALHM1) found in early onset Alzheimer's disease patients alter calcium homeostasis. PLoS ONE 2013:8(9):e74203.
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Rusanen M, Ngandu T, Laatikainen T, Tuomilehto J, Soininen H, Kivipelto M. Chronic obstructive pulmonary disease and asthma and the risk of mild cognitive impairment and dementia: a population based CAIDE study. Curr Alzheimer Res
2013:10(5):549-555.
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Räisänen S, Sokka A, Georgiadis L, Harju M, Gissler M, Keski-Nisula L, Kälviäinen R, Heinonen S. Infertility treatment and umbilical cord length - novel markers of childhood epilepsy? PLoS ONE 2013:8(2):e55394.
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Salminen A, Kaarniranta K, Kauppinen A. Crosstalk between oxidative stress and SIRT1: Impact on the aging process. Int J Mol Sci 2013:14(2):3834-3859.
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Salminen A, Kaarniranta K, Kauppinen A. Beclin 1 interactome controls the crosstalk between apoptosis, autophagy and inflammasome activation: Impact on the aging process. Ageing Res Rev 2013:12(2):520-534.
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Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome. Prog Neurobiol 2013:106-107:33-54.
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Seppälä T, Herukka SK, Remes AM. Alzheimerin taudin varhaisdiagnostiikka. Duodecim 2013:129:2003-2010.
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Sipola P, Hedman M, Onatsu J, Turpeinen A, Halinen M, Jäkälä P, Vanninen R. Computed tomography and echocardiography together reveal more high-risk findings than echocardiography alone in the diagnostics of stroke etiology. Cerebrovasc Dis
2013:35(6):521-530.
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Solomon A, Kivipelto M, Soininen H. Prevention of Alzheimer's disease: moving backward through the lifespan. J Alzheimers Dis 2013:33:S465-S469.
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Spulber G, Simmons A, ..., Soininen H, Spenger C, Lovestone S, Wahlund L-O, Westman E. An MRI-based index to measure the severity of Alzheimer?s disease-like structural pattern in subjects with mild cognitive impairment. J Intern Med
2013:273(4):396-409.
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51 |
Suoranta S, Holli-Helenius K, Koskenkorva P, Niskanen E, Könönen M, Äikiä M, Eskola H, Kälviäinen R, Vanninen R. 3D texture analysis reveals imperceptible MRI textural alterations in the thalamus and putamen in progressive myoclonic epilepsy type 1,
EPM1. PLoS ONE 2013:8(7):e69905.
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Taina M, Vanninen R, Hedman M, Jäkälä P, Kärkkäinen S, Tapiola T, Sipola P. Left atrial appendage volume increased in more than half of patients with cryptogenic stroke. PLoS ONE 2013:8(11):e79519.
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Takalo M, Haapasalo A, Natunen T, Viswanathan J, Kurkinen KM, Tanzi RE, Soininen H, Hiltunen M. Targeting ubiquilin-1 in Alzheimer's disease. Expert Opin Ther Targets 2013:17(7):795-810.
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Takalo M, Salminen A, Soininen H, Hiltunen M, Haapasalo A. Protein aggregation and degradation mechanisms in neurodegenerative diseases. Am J Neurodegener Dis 2013:2(1):1-14.
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Tolppanen A-M, Lavikainen P, Soininen H, Hartikainen S. Incident hip fractures among community dwelling persons with Alzheimer?s Disease in a Finnish Nationwide Register-Based Cohort. PLoS ONE 2013:8(3):e59124.
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56 |
Tolppanen AM, Kettunen R, Ahonen R, Soininen H, Hartikainen S. Incident ischaemic heart disease in persons with Alzheimer?s disease in a Finnish nationwide exposure-matched cohort. Int J Cardiol 2013:170(2):195-201.
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Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Soininen H, Hartikainen S. Incidence of stroke in people with Alzheimer disease. . A national register-based approach. Neurology 2013:80(4):353-358.
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Tolppanen AM, Lavikainen P, Solomon A, Kivipelto M, Uusitupa M, Soininen H, Hartikainen S. History of medically treated diabetes and risk of Alzheimer disease in a nationwide case-control study. Diabetes Care 2013:36(7):2015-2019.
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59 |
Trinka E, Marson AG, Van Paesschen W, Kälviäinen R, Marovac J... KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium
valproate as monotherapy in patients with newly diagnosed epilepsy. J Neurol Neurosurg Psychiatry 2013:84(10):1138-1147.
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60 |
Velayudhan L, Proitsi P, ..., Soininen H, ..., Hodges A, Powell J, Lovestone S, Simmons A. Entorhinal cortex thickness predicts cognitive decline in Alzheimer?s disease. J Alzheimers Dis 2013:33(3):755-766.
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61 |
Vermeiren APA, Bosma H, ..., Soininen H, ..., Wahlund L-O, Vellas B, Wilcock G, Elias-Sonnenschein LS, Verhey FRJ. The association between APOE e4 and Alzheimer-type dementia among memory clinic patients is confined to those with a higher education.
The DESCRIPA Study. J Alzheimers Dis 2013:35(2):241-246.
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Viiri J, Amadio M, Marchesi N, Hyttinen JMT, Kivinen N, Sironen R, Rilla K, Akhtar S, Provenzani A, D'Agostino VG, Govoni S, Pascale A, Agostini H, Petrovski G, Salminen A, Kaarniranta K. Autophagy activation clears ELAVL1/HuR-mediated accumulation
of SQSTM1/p62 during proteasomal inhibition in human retinal pigment epithelial cells. PLoS ONE 2013:8(7):e69563.
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Viswanathan J, Haapasalo A, ..., Soininen H, Tanzi RE, Hiltunen M. Ubiquilin-1 modulates y-secretase-mediated e-site cleavage in neuronal cells. Biochemistry 2013:52(22):3899-3912.
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Vos SJB, van Rossum IA, Verhey F, ..., Soininen H, ..., Wolz R, Scheltens P, Visser PJ. Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI. Neurology 2013:80(12):1124-1132.
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Vuorinen M, Kåreholt I, ..., Soininen H, Kivipelto M, Solomon A. Changes in vascular factors 28 years from midlife and late-life cortical thickness. Neurobiol Aging 2013:34(1):100-109.
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