Neurologian yksikkö
Department of Neurology

Julkaisut 2021
Publications 2021

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1 Baumgartner T, Carreno M, Rocamora R, Bisulli F, Boni A, Brázdil M, Horak A, Craiu D, Pereira C, Guerrini R, ..., Kälviäinen R, et al. A survey of the European Reference Network EpiCARE on clinical practice for selected rare epilepsies. Epilepsia Open 2021:6(1):160-170.
2 de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, Sims R, ..., Soininen H, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun 2021:12(1):3417.
3 Deckers K, Köhler S, Ngandu T, Antikainen R, Laatikainen T, Soininen H, Strandberg T, Verhey F, Kivipelto M, Solomon A. Quantifying dementia prevention potential in the FINGER randomized controlled trial using the LIBRA prevention index. Alzheimers Dement 2021:17(7):1205-1212.
4 Frederiksen KS, Nielsen TR, Appollonio I, Andersen BB, Riverol M, Boada M, Ceccaldi M, Dubois B, Engelborghs S, Frölich L, Hausner L, Gabelle A, Gabryelewicz T, Grimmer T, Hanseeuw B, Hort J, Hugon J, Jelic V, Koivisto A, et al. Biomarker counseling, disclosure of diagnosis and follow-up in patients with mild cognitive impairment: A European Alzheimer's disease consortium survey. Int J Geriatr Psychiatry 2021:36(2):324-333.
5 Gharahkhani P, Jorgenson E, Hysi P, Khawaja AP, ..., Mannermaa A, ..., Kosma V-M, ..., Paloneva J, ..., Kuopio T, ..., Harvima I, Pihlajamäki J, Kaarniranta K, Pelkonen M, Laakso M, ..., Kaipiainen-Seppänen O, Auvinen P, Kälviäinen R, et al. Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nat Commun 2021:12(1):1258.
6 Gleichgerrcht E, Munsell BC, Alhusaini S, Alvim MK, Bargalló N, Bender B, Bernasconi A, Bernasconi N, Bernhardt B, Blackmon K, Caligiuri ME, Cendes F, Concha L, Desmond PM, Devinsky O, Doherty CP, Domin M, ..., Kälviäinen R, et al. Artificial intelligence for classification of temporal lobe epilepsy with ROI-level MRI data: A worldwide ENIGMA-Epilepsy study. Neuroimage Clin 2021:31:102765.
7 Hyppönen J, Hakala A, Annala K, Zhang H, Peltola J, Mervaala E, Kälviäinen R. Automatic assessment of the myoclonus severity from videos recorded according to standardized Unified Myoclonus Rating Scale protocol and using human pose and body movement analysis. Seizure 2021:76:72-78.
8 Jetsonen V, Kuvaja-Köllner V, Välimäki T, Selander T, Martikainen J, Koivisto AM. Total cost of care increases significantly from early to mild Alzheimer's disease: 5-year ALSOVA follow-up. Age Ageing 2021:50(6):2116-2122.
9 Junkkari A, Sintonen H, Danner N, Jyrkkänen HK, Rauramaa T, Luikku AJ, Koivisto AM, Roine RP, Viinamäki H, Soininen H, Jääskeläinen JE, Leinonen V. 5-Year health-related quality of life outcome in patients with idiopathic normal pressure hydrocephalus. J Neurol 2021:268(9):3283-3293.
10 Jutila L, Kälviäinen R, Miettinen R, Immonen A. Epilepsian leikkaushoito. Pinsetti 2021:33(1):14-19.
11 Järvelä I, Määttä T, Acharya A, Leppälä J, Jhangiani SN, Arvio M, Siren A, Kankuri-Tammilehto M, Kokkonen H, Palomäki M, Varilo T, Fang M, Hadley TD, Jolly A, Linnankivi T, Paetau R, Saarela A, Kälviäinen R, et al. Exome sequencing reveals predominantly de novo variants in disorders with intellectual disability (ID) in the founder population of Finland. Hum Genet 2021:140(7):1011-1029.
12 Kaipainen AL, Pitkänen J, Haapalinna F, Jääskeläinen O, Jokinen H, Melkas S, Erkinjuntti T, Vanninen R, Koivisto AM, Lötjönen J, Koikkalainen J, Herukka S, Julkunen V. A novel CT-based automated analysis method provides comparable results with MRI in measuring brain atrophy and white matter lesions. Neuroradiology 2021:63(12):2035-2046.
13 Karhi S, Tähtinen O, Aherto J, Matikka H, Manninen H, Nerg O, Taina M, Jäkälä P, Vanninen R. Effect of different thresholds for CT perfusion volumetric analysis on estimated ischemic core and penumbral volumes. PLoS ONE 2021:16(4):e0249772.
14 Katisko K, Cajanus A, Huber N, Jääskeläinen O, Kokkola T, Kärkkäinen V, Rostalski H, Hartikainen P, Koivisto AM, Hannonen S, Lehtola J, Korhonen VE, Helisalmi S, Koivumaa-Honkanen H, Herukka S, Remes AM, Solje E, Haapasalo A. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance. J Neurol Neurosurg Psychiatry 2021:92(12):1305-1312.
15 Koko M, Krause R, Sander T, Bobbili DB, Nothnagel M, ..., Kälviäinen R, et al. Distinct gene-set burden patterns underlie common generalized and focal epilepsies. EBioMedicine 2021:72:103588.
16 Kolehmainen L, Havulinna S, Ngandu T, Strandberg T, Levälahti E, Lehtisalo J, Antikainen R, Hietikko E, Peltonen M, Pölönen A, Soininen H, Tuomilehto J, Laatikainen T, Rauramaa R, Kivipelto M, Kulmala J. Earlier life leisure-time physical activity in relation to age-related frailty syndrome. Age Ageing 2021:50(1):161-168.
17 Komulainen P, Tuomilehto J, Savonen K, Männikkö R, Hassinen M, Lakka TA, Hänninen T, Kiviniemi V, Jacobs DR, Kivipelto M, Rauramaa R. Exercise, diet, and cognition in a 4-year randomized controlled trial: Dose-Responses to Exercise Training (DR's EXTRA). Am J Clin Nutr 2021:113(6):1428-1439.
18 Kulmala J, Tiilikainen E, Lisko I, Ngandu T, Kivipelto M, Solomon A. Personal Social Networks of Community-Dwelling Oldest Old During the Covid-19 Pandemic-A Qualitative Study. Front Public Health 2021:9:770965.
19 Lukkarinen H, Tesseur I, Pemberton D, Van Der Ark P, Timmers M, Slemmon R, Janssens L, Streffer J, Van Nueten L, Bottelbergs A, Rauramaa T, Koivisto AM, Herukka S, Korhonen VE, Junkkari A, Hiltunen M, Engelborghs S, Blennow K, Zetterberg H, et al. Time Trends of Cerebrospinal Fluid Biomarkers of Neurodegeneration in Idiopathic Normal Pressure Hydrocephalus. J Alzheimer Dis 2021:80(4):1629-1642.
20 Manmohi DD, De Marco M, Blackburn DJ, Wilkinson ID, Remes A, Liu Y, Pikkarainen M, Hallikainen M, Soininen H, Venneri A. Obesity and Brain Vulnerability in Normal and Abnormal Aging: A Multimodal MRI Study. J Alzheimers Dis Rep 2021:5(1):65-77.
21 Martinez-Majander N, Artto V, Ylikotila P, von Sarnowski B, Waje-Andreassen U, Yesilot N, Zedde M, Huhtakangas J, Numminen H, Jäkälä P, Fonseca AC, Redfors P, Wermer MJH, Pezzini A, Putaala J. Association between Migraine and Cryptogenic Ischemic Stroke in Young Adults. Ann Neurol 2021:89(2):242-253.
22 Nakajima M, Rauramaa T, Mäkinen PM, Hiltunen M, Herukka S-K, Kokki M, Musialowicz T, Jyrkkänen H-K, Danner N, Junkkari A, Koivisto AM, Jääskeläinen JE, Miyajima M, Ogino I, Furuta A, Akiba C, Kawamura K, Kamohara C, ..., Leinonen V, Arai H. Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus. Eur J Neurol 2021:28(2):389-400.
23 Nerg O, Junkkari A, Hallikainen I, Rauramaa T, Luikku A, Hiltunen M, Jääskeläinen JE, Leinonen V, Hänninen T, Koivisto A. The CERAD Neuropsychological Battery in Patients with Idiopathic Normal Pressure Hydrocephalus Compared with Normal Population and Patients with Mild Alzheimer's Disease. J Alzheimer Dis 2021:81(3):1117-1130.
24 Ngandu Tiia, ..., Coley Nicola, Antikainen Riitta, Bäckman Lars, Hänninen Tuomo, Lindström Jaana, Laatikainen Tiina, Paajanen Teemu, Havulinna Satu, Peltonen Markku, Neely Anna S, Strandberg Timo, Tuomilehto Jaakko, Soininen Hilkka, Kivipelto Miia. The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER). Alzheimers Dement 2021:18(7):1325-1334.
25 Niiranen M, Kontkanen A, Jääskeläinen O, Tertsunen H-M, Selander T, Hartikainen P, Huber N, Solje E, Haapasalo A, Kokkola T, Lohioja T, Herukka S-K, Simula S, Remes AM. Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis. Mult Scler Relat Disord 2021:56:103280.
26 Puurunen A, Ikäheimo T-M, Nissen M, Huotarinen A, Jyrkkänen H-K, Huttunen J, Koivisto T, von Und Zu Fraunberg M, Kajanus M. A hybrid SWOT analysis of the neuromodulation process for chronic pain. Br J Neurosci Nurs 2021:16(2):76.
27 Rissanen SM, Hyppönen J, Silvennoinen K, Säisänen L, Karjalainen PA, Mervaala E, Kälviäinen R. Wearable monitoring of positive and negative myoclonus in progressive myoclonic epilepsy type 1. Clin Neurophysiol 2021:132(10):2464-2472.
28 Rosenberg A, Solomon A, Soininen H, Visser PJ, Blennow K, Hartmann T, Kivipelto M. Research diagnostic criteria for Alzheimer's disease: findings from the LipiDiDiet randomized controlled trial. Alzheimers Res Ther 2021:13(1):64.
29 Ruotsalainen SE, Partanen JJ, Cichonska A, ..., Pulkki K, Kaarteenaho R, Kosma V-M, Mannermaa A, Paloneva J, Soininen H, Remes A, Kälviäinen R, Hiltunen M, Kaipiainen-Seppänen O, Pelkonen M, Laakso M, Pihlajamäki J, Laukkanen J, Auvinen P, Kaarniranta K, Harvima I, Kurki M, Kuopio T. An expanded analysis framework for multivariate GWAS connects inflammatory biomarkers to functional variants and disease. Eur J Hum Genet 2021:29(2):309-324.
30 Rusanen M, Selander T, Kärkkäinen V, Koivisto A. The Positive Effects of Pet Ownership on Alzheimer's Disease. J Alzheimer Dis 2021:84(4):1669-1675.
31 Sairanen JJ, Kantanen A-M, Hyppölä HT, Kälviäinen R. Status epilepticus: Practice variation and adherence to treatment guideline in a large community hospital. J Neurol Sci 2021:427:117542.
32 Sandebring-Matton A, Goikolea J, Björkhem I, Paternain L, Kemppainen N, Laatikainen T, Ngandu T, Rinne J, Soininen H, Cedazo-Minguez A, Solomon A, Kivipelto M. 27-Hydroxycholesterol, cognition, and brain imaging markers in the FINGER randomized controlled trial. Alzheimers Res Ther 2021:13(1):56.
33 Sarli G, De Marco M, Hallikainen M, Soininen H, Bruno G, Venneri A. Regional Strength of Large-Scale Functional Brain Networks is Associated with Regional Volumes in Older Adults and in Alzheimer's Disease. Brain Connect 2021:11(3):201-212.
34 Seyedeh FATEMEH Salimi Ashkezari 1, ..., Fady T Charbel 6, Behnam REZAI Jahromi 7, Mika NIEMELÄ 8, KOIVISTO, FROSEN, Yasutaka TOBE 12 13, Spandan MAITI 12, Anne M Robertson 12 13, Juan R Cebral 2. Prediction of bleb formation in intracranial aneurysms using machine learning models based on aneurysm hemodynamics, geometry, location, and patient population. J Neurointerv Surg 2021.
35 Sindi S, Solomon A, Kåreholt I, Hovatta I, Antikainen R, Hänninen T, Levälahti E, Laatikainen T, Lehtisalo J, Lindström J, Paajanen T, Peltonen M, Singh Khalsa D, Wolozin B, Strandberg T, Tuomilehto J, Soininen H, Ngandu T, Kivipelto M. Telomere length change in a multidomain lifestyle intervention to prevent cognitive decline: a randomized clinical trial. J Gerontol A Biol Sci Med Sci 2021:76(3):491-498.
36 Sipilä J, Kälviäinen R. Unverricht-Lundborgin taudin epidemiologia Suomessa : esimerkki perinnöllisen harvinaissairauden tutkimisen epävarmuudesta. Duodecim 2021:137(11):1126-1126.
37 Sipilä S, Tirkkonen A, Savikangas T, Hänninen T, Laukkanen P, Alen M, Fielding RA, Kivipelto M, Kulmala J, Rantanen T, Sihvonen SE, Sillanpää E, Stigsdotter Neely A, Törmäkangas T. Effects of physical and cognitive training on gait speed and cognition in older adults: A randomized controlled trial. Scand J Med Sci Sports 2021:31(7):1518-1533.
38 Sirkka J, Parviainen M, Jyrkkänen HK, Koivisto AM, Säisänen L, Rauramaa T, Leinonen V, Danner N. Upper limb dysfunction and activities in daily living in idiopathic normal pressure hydrocephalus. Acta Neurochir (Wien) 2021:163(10):2675-2683.
39 Soininen H, Solomon A, Visser PJ, Hendrix SB, Blennow K, Kivipelto M, Hartmann T. 36-month LipiDiDiet multinutrient clinical trial in prodromal Alzheimer's disease. Alzheimers Dement 2021:17(1):29-40.
40 Solomon A, Handels R, Wimo A, Antikainen R, Laatikainen T, Levälahti E, Peltonen M, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M, Ngandu T. Effect of a Multidomain Lifestyle Intervention on Estimated Dementia Risk. J Alzheimer Dis 2021:82(4):1461-1466.
41 Stephen R, Ngandu T, Liu Y, Peltonen M, Antikainen R, Kemppainen N, Laatikainen T, Lötjönen J, Rinne J, Strandberg T, Tuomilehto J, Vanninen R, Soininen H, Kivipelto M, Solomon A. Change in CAIDE Dementia Risk Score and Neuroimaging Biomarkers During a 2-Year Multidomain Lifestyle Randomized Controlled Trial: Results of a Post-Hoc Subgroup Analysis. J Gerontol A Biol Sci Med Sci 2021:76(8):1407-1414.
42 Strausz S, Kiiskinen T, Broberg M, Ruotsalainen S, Koskela J, Bachour A, Palotie A, Palotie T, Ripatti S, Ollila HM, ..., Kosma V-M, ..., Mannermaa A, Paloneva J, ..., Kälviäinen R, ..., Kaipiainen-Seppänen O, ..., Laakso M, Pihlajamäki J, ..., Kaarniranta K, ..., Harvima I, ..., Kuopio T. Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respir Res 2021:8(1):e000845.
43 van Oudenhoven FM, Swinkels SH, Soininen H, Kivipelto M, Hartmann T, Rizopoulos D. A competing risk joint model for dealing with different types of missing data in an intervention trial in prodromal Alzheimer's disease. Alzheimers Res Ther 2021:13(1):63.
44 van Waalwijk van Doorn LJ, Ghafoorian M, van Leijsen EM, Claassen JA, Arighi A, Bozzali M, Cannas J, Cavedo E, Eusebi P, Farotti L, Fenoglio C, Fortea J, Frisoni GB, Galimberti D, Greco V, Herukka S, Liu Y, Lleó A, de Mendonça A, Nobili FM, Pikkarainen Maria, Soininen Hilkka, et al. White Matter Hyperintensities Are No Major Confounder for Alzheimer's Disease Cerebrospinal Fluid Biomarkers. J Alzheimer Dis 2021:79(1):163-175.
45 Vanninen A, Nakajima M, Miyajima M, Rauramaa T, Kokki M, Musialowicz T, Mäkinen PM, Herukka S, Koivisto AM, Jääskeläinen JE, Hiltunen M, Leinonen V. Elevated CSF LRG and Decreased Alzheimer's Disease Biomarkers in Idiopathic Normal Pressure Hydrocephalus. J Clin Med 2021:10(5):1105.
46 Whiley L, Chappell KE, D'Hondt E, Lewis MR, Jiménez B, Snowden SG, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Swann JR, Hye A, Lovestone S, Legido-Quigley C, Holmes E. Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease. Alzheimers Res Ther 2021:13(1):20.
47 Ylä-Herttuala S, Hakulinen M, Poutiainen P, Laitinen TM, Koivisto AM, Remes AM, Hallikainen M, Lehtola J, Saari T, Korhonen V, Könönen M, Vanninen R, Mussalo H, Laitinen T, Mervaala E. Severe Obstructive Sleep Apnea and Increased Cortical Amyloid-ß Deposition . J Alzheimer Dis 2021:79(1):153-161.
48 Zekavat SM, Lin S, Bick AG, ..., Mannermaa A, ..., Soininen H, ..., Huhtakangas J, ..., Pihlajamäki J, ..., Kaarniranta K, ..., Tuppurainen M, ..., Kaipiainen-Seppänen O, ..., Kälviäinen R, ..., Kosma VM, et al. Hematopoietic mosaic chromosomal alterations increase the risk for diverse types of infection. Nat Med 2021:27(6):1012-1024.
49 Äikiä M, Hyppönen J, Mervaala E, Kälviäinen R. Cognitive functioning in progressive myoclonus epilepsy type 1 (Unverricht-Lundborg Disease, EPM1). Epilepsy Behav 2021:122:108157.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 19.8.2022 Publications Data Base 19.8.2022