Neurologian yksikkö
Department of Neurology

Julkaisut 2014
Publications 2014

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1 Aguilar C1, Muehlboeck JS2, Mecocci P3, Vellas B4, Tsolaki M5, Kloszewska I6, Soininen H7, Lovestone S8, Wahlund LO1, Simmons A8, Westman E1, AddNeuroMed Consortium. Application of a MRI based index to longitudinal atrophy change in Alzheimer disease, mild cognitive impairment and healthy older individuals in the AddNeuroMed cohort. Front Aging Neurosci 2014:14(6):145.
2 Chincarini A, Bosco P, Gemme G, ..., Soininen H, ... Automatic temporal lobe atrophy assessment in prodromal AD: Data from the DESCRIPA study. Alzheimers Dement 2014:10(4):456-67.
3 Di Marco LY1, Marzo A1, Muñoz-Ruiz M2, Ikram MA3, Kivipelto M2, Ruefenacht D4, Venneri A5, Soininen H, Wanke I4, Ventikos YA6, Frangi AF. Modifiable Lifestyle Factors in Dementia: A Systematic Review of Longitudinal Observational Cohort Studies. J Alzheimer Dis 2014:42(1):119-35.
4 Doyle OM1, Westman E2, Marquand AF1, Mecocci P3, Vellas B4, Tsolaki M5, Kloszewska I6, Soininen H7, Lovestone S8, Williams SCR9, Simmons A. Predicting progression of Alzheimer's disease using ordinal regression. PLoS ONE 2014:9(8):e105542.
5 Duits FH, Teunissen CE, Bouwman FH, ..., Herukka SK, ..., van der Flier WM. The cerebrospinal fluid "Alzheimer profile": easily said, but what does it mean? Alzheimers Dement 2014:10(6):713-723.
6 Elobeid A1, Rantakömi S2, Soininen H, Alafuzoff I4. Alzheimer's disease-related plaques in nondemented subjects. Alzheimers Dement 2014:10(5):522-9.
7 Escott-Price V1, Bellenguez C2, Wang LS3, Choi SH4, ..., Soininen H, ..., Amouyel P121, Williams J1, Cardiovascular Health Study (CHS). Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. PLoS ONE 2014:9(6):e94661.
8 Hallikainen I, Martikainen J, Lin PJ, Cohen J T, Lahoz R, Välimäki T, Hongisto K, Väätäinen S, Vanhanen M, Neumann P J, Hänninen T, Koivisto AM. The Progression of Alzheimer's Disease Can Be Assessed with a Short Version of the CERAD Neuropsychological Battery: The Kuopio ALSOVA Study. Dement Geriatr Cogn Disord Extra 2014(4):494-508.
9 Hartmann T1, van Wijk N2, Wurtman RJ3, Olde Rikkert MG4, Sijben JW2, Soininen H, Vellas B6, Scheltens P. A Nutritional Approach to Ameliorate Altered Phospholipid Metabolism in Alzheimer's Disease. J Alzheimer Dis 2014:41(3):715-7.
10 Helisalmi S1, Hall A, Meriläinen EH, Väisänen V, Koivisto AM, Herukka SK, Laitinen M, Soininen H, Hiltunen M. The Effect of TOMM40 Poly-T Repeat Lengths on Age of Onset and Cerebrospinal Fluid Biomarkers in Finnish Alzheimer's Disease Patients. Neurodegenerative Dis 2014:14(4):204-8.
11 Hye A1, Riddoch-Contreras J1, Baird AL1, Ashton NJ1, ..., Soininen H, ..., Mecocci P11, Tsolaki M12, Vellas B13, Lovestone S14. Plasma proteins predict conversion to dementia from prodromal disease. Alzheimers Dement 2014:10(6):799-807.
12 Hynynen J, Komulainen T, Tukiainen E, Nordin A, Arola J, Kälviäinen R, Jutila L, Röyttä M, Hinttala R, Majamaa K, Mäkisalo H, Uusimaa J. Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation. Liver Transplant 2014:20(11):1402-12.
13 Hyttinen JMT1, Amadio M2, Viiri J3, Pascale A2, Salminen A4, Kaarniranta K5. Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases. Ageing Res Rev 2014:18:16-28.
14 Imtiaz B1, Tolppanen AM2, Kivipelto M3, Soininen H. Future directions in Alzheimer's disease from risk factors to prevention. Biochem Pharmacol 2014:88(4):661-70.
15 Imtiaz B1, Tuppurainen M, Tiihonen M3, Kivipelto M4, Soininen H, Hartikainen S6, Tolppanen AM. Oophorectomy, Hysterectomy, and Risk of Alzheimer's Disease: A Nationwide Case-Control Study. J Alzheimer Dis 2014:42(2):575-81.
16 International League Against Epilepsy Consortium on Complex Epilepsies, Anney RJL, ...., Kälviäinen R, Kantanen A, ..., Zimprich F. Genetic determinants of common epilepsies: a meta-analysis of genome-wide association studies. Lancet Neurol 2014:13(9):893-903.
17 Jutila L1, Aikiä M2, Immonen A3, Mervaala E4, Alafuzoff I5, Kälviäinen R. Long-term memory performance after surgical treatment of unilateral temporal lobe epilepsy (TLE). Epilepsy Res 2014:108(7):1228-37.
18 Kauppinen A, Nevalainen T, Hytti M, Salminen A, Kaarniranta K, Parkkari T. CB2 receptor as a potential target in age-related diseases. J Biochem Pharmacol Res 2014:2(1):33-43.
19 Kiddle SJ1, Sattlecker M, Proitsi P, Simmons A, Westman E, Bazenet C, Nelson SK, Williams S, Hodges A, Johnston C, Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Newhouse S, Lovestone S, Dobson RJB. Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study. J Alzheimer Dis 2014:38(3):515-31.
20 Kimiskidis VK1, Valentin A, Kälviäinen R. Transcranial magnetic stimulation for the diagnosis and treatment of epilepsy. Curr Opin Neurol 2014:27(2):236-41.
21 Kivinen N, Hyttinen JMT, Viiri J, Paterno JJ, Szabolcs F, Kauppinen A, Salminen A, Kaarniranta K. Hsp70 binds reversibly to proteasome inhibitor-induced protein aggregates and evades autophagic clearance in ARPE-19 cells. J Biochem Pharmacol Res 2014:2(1):1-7.
22 Kivistö J, Soininen H, Pihlajamäki M. Functional MRI in Alzheimer's Disease. In: Papageorgiou D, Christopoulos G, Smirnakis S, eds. Advanced Brain Neuroimaging Topics in Health and disease - Methods and Applications, p. 497-519. InTech, 2014.
23 Kulmala J1, Solomon A, Kåreholt I, Ngandu T, Rantanen T, Laatikainen T, Soininen H, Tuomilehto J, Kivipelto M. Association between mid- to late life physical fitness and dementia: evidence from the CAIDE study. J Intern Med 2014:276(3):296-307.
24 Kälviäinen R. Pitkittyneen epilepsiakohtauksen ja status epilepticuksen hoito. Kirjassa: Jousimaa J, Alenius H, Atula S, Kattainen A, Pelttari H, Kunnamo I, Teikari M, toim. Lääkärin käsikirja, s. 1349--1350. Helsinki: Duodecim, 2014.
25 Kälviäinen R. Aikuisen epilepsian hoito. Kirjassa: Jousimaa J, Alenius H, Atula S, Kattainen A, Pelttari H, Kunnamo I, Teikari M, toim. Lääkärin käsikirja, s. 1350-1353. Helsinki: Duodecim, 2014.
26 Kälviäinen R, Ansakorpi H, Flander S, Immonen A, Keränen T, Kivistö J, Peltola J. Epilepsiat (aikuiset) Käypä hoito -suositus. Duodecim 2014:130(7):748-9.
27 Kälviäinen R, Mervaala E. Epileptisen kohtauksen saaneen potilaan tutkiminen. Kirjassa: Jousimaa J, Alenius H, Atula S, Kattainen A, Kunnamo I, Pelttari H, Teikari M, toim. Lääkärin käsikirja, s. 1346-1348. Helsinki: Duodecim, 2014.
28 Laiterä T1, Sarajärvi T2, Haapasalo A2, Puli L3, Kauppinen T2, Mäkinen P2, Rauramaa T4, Tanila H3, Jääskeläinen JE1, Alafuzoff I5, Soininen H6, Leinonen V1, Hiltunen M2. Increased gamma-secretase activity in idiopathic normal pressure hydrocephalus patients with ß-amyloid pathology. PLoS ONE 2014:9(4):e93717.
29 Lautner R, Palmqvist S, Mattsson N, ..., Wallin A, Pålsson E, Jakobsson J, Herukka SK, Owenius R, Olsson B, Hampel H, Rujescu D, Ewers M8, Landén M, Minthon L, Blennow K1, Zetterberg H, Hansson O, Alzheimer’s Disease Neuroimaging Initiative. Apolipoprotein E Genotype and the Diagnostic Accuracy of Cerebrospinal Fluid Biomarkers for Alzheimer Disease. JAMA Psychiatry 2014:71(10):1183-91.
30 Lebedev AV1, Westman E2, van Westen GJ3, Kramberger MG4, Lundervold A5, Aarsland D6, Soininen H, Kloszewska I8, Mecocci P9, Tsolaki M10, Vellas B11, Lovestone S12, Simmons A12. Random Forest ensembles for detection and prediction of Alzheimer's disease with a good between-cohort robustness. Neuroimage Clin 2014:28(6):115-25.
31 Lehesjoki AE, Kälviäinen R. Unverricht-Lundborg Disease. In: Pagon RA, Adam MP, Ardinger HH, et al., eds. GeneReviews. Seattle: University of Washington, 2014.
32 Lindsberg PJ, Castrén E, ..., Isometsä E, Kalso E, Marttunen M, Pihko H, Tienari P, Wartiovaara A, Jäkälä P, Kälviäinen R, Soininen H, Tiihonen J, Karlsson H, Rinne J, Roine RO, Elovaara I, Tamminen T, Öhman J, Majamaa K, Hari R. Aivosairaudet ovat kalleimmat kansantautimme. Duodecim 2014:130(17):1721-30.
33 Morris JC1, Blennow K, Froelich L, Nordberg A, Soininen H, Waldemar G, Wahlund LO, Dubois B. Harmonized diagnostic criteria for Alzheimer's disease: recommendations. J Intern Med 2014:275(3):204-13.
34 Munoz-Ruiz MA, Hall A, Mattila J, Koikkalainen J, Herukka SK, Vanninen R, Liu Y, Lötjönen J, Soininen H. Comparing Predictors of Conversion to Alzheimer's Disease Using the Disease State Index. Neurodegenerative Dis 2014:13(2-3):200-2.
35 Neuvonen E1, Rusanen M1, Solomon A1, Ngandu T1, Laatikainen T1, Soininen H, Kivipelto M1, Tolppanen AM2. Late-life cynical distrust, risk of incident dementia, and mortality in a population-based cohort. Neurology 2014:82(24):2205-12.
36 Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and baseline characteristics of participants in the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)-a randomized controlled lifestyle trial. Int J Environ Res Public Health 2014:11(9):9345-60.
37 Nikolaev A, Pääkkönen A, Niemi J, Nissi M J, Niskanen E, Könönen M, Mervaala E, Soininen H. Behavioural and ERP effects of paradigm complexity on visual word recognition. Lang Cogn Neurosci 2014:29(10):1295-1310.
38 Ojala M, Kälviäinen R. Epilepsia ja ajokyky. Epilepsia-lehti 2014(2):4-6.
39 Paajanen T, Hänninen T, Tunnard C3, Hallikainen M, Mecocci P4, Sobow T5, Tsolaki M6, Vellas B7, Lovestone S8, Soininen H. CERAD neuropsychological compound scores are accurate in detecting prodromal alzheimer's disease: a prospective AddNeuroMed study. J Alzheimer Dis 2014:39(3):679-90.
40 Pereira JB, Cavallin L, Spulber G, Aguilar C, Mecocci P, Vellas B, Tsolaki M, Kloszewska I, Soininen H, Spenger C, Aarsland D, Lovestone S, Simmons A, Wahlund LO, Westman E. Influence of age, disease onset and ApoE4 on visual medial temporal lobe atrophy cut-offs. J Intern Med 2014:275(3):317-30.
41 Piippo N, Korkmaz A, Hytti M, Kinnunen K, Salminen A, Atalay M, Kaarniranta K, Kauppinen A. Decline in cellular clearance systems induces inflammasome signaling in human ARPE-19 cells. Biochim Biophys Acta 2014:1843(12):3038-46.
42 Portelius E1, Hölttä M, Soininen H, Bjerke M, Zetterberg H, Westerlund A, Herukka SK, Blennow K, Mattsson N. Altered cerebrospinal fluid levels of amyloid ß and amyloid precursor-like protein 1 peptides in Down's syndrome. Neuromolecular Med 2014:16(2):510-6.
43 Portelius E1, Soininen H, Andreasson U, Zetterberg H, Persson R, Karlsson G, Blennow K, Herukka SK, Mattsson N. Exploring Alzheimer molecular pathology in Down's syndrome cerebrospinal fluid. Neurodegenerative Dis 2014:14(2):98-106.
44 Proitsi P, ..., Soininen Hilkka, ..., Powell JF. Alleles that increase risk for type 2 diabetes mellitus are not associated with increased risk for Alzheimer's disease. Neurobiol Aging 2014:35(12):2883.e3-2883.
45 Proitsi P, Lee SH, Lunnon K, ..., Soininen H, ..., Hodges A. Alzheimer's disease susceptibility variants in the MS4A6A gene are associated with altered levels of MS4A6A expression in blood. Neurobiol Aging 2014:35(2):279-290.
46 Proitsi P, Lupton MK, Velayudhan L, Newhouse S, Fogh I, Tsolaki M, Daniilidou M, Pritchard M, Kloszewska I, Soininen H, ..., Lovestone S, Powell JF. Genetic predisposition to increased blood cholesterol and triglyceride lipid levels and risk of Alzheimer disease: a mendelian randomization analysis. PLoS Medicine 2014:11(9):e1001713.
47 Pyykkö OT, Lumela M, Rummukainen J, Nerg O, Seppälä TT4, Herukka SK, Koivisto AM, Alafuzoff I6, Puli L4, Savolainen S, Soininen H, Jääskeläinen JE, Hiltunen M4, Zetterberg H7, Leinonen V. Cerebrospinal fluid biomarker and brain biopsy findings in idiopathic normal pressure hydrocephalus. PLoS ONE 2014:9(3):e91974.
48 Rinne JO1, Frantzen J, Leinonen V, Lonnrot K, Laakso A, Virtanen KA, Solin O, Kotkansalo A, Koivisto A, Sajanti J, Karppinen A, Lehto H, Rummukainen J, Buckley C, Smith A, Jones PA, Sherwin P, Farrar G, McLain R, Kailajarvi M, Grachev ID. Prospective flutemetamol positron emission tomography and histopathology in normal pressure hydrocephalus. Neurodegenerative Dis 2014:13(4):237-45.
49 Runtti H1, Mattila J1, van Gils M1, Koikkalainen J1, Soininen H, Lötjönen J, Alzheimer’s Disease Neuroimaging Initiative. Quantitative evaluation of disease progression in a longitudinal mild cognitive impairment cohort. J Alzheimer Dis 2014:39(1):49-61.
50 Rusanen M1, Kivipelto M2, Levälahti E3, Laatikainen T4, Tuomilehto J5, Soininen H6, Ngandu T7. Heart Diseases and Long-Term Risk of Dementia and Alzheimer's Disease: A Population-Based CAIDE Study. J Alzheimer Dis 2014:42(1):183-91.
51 Salminen A, Kaarniranta K, Hiltunen M, Kauppinen A. Histone demethylase Jumonji D3 (JMJD3/KDM6B) at the nexus of epigenetic regulation of inflammation and the aging process. J Mol Med 2014:92(10):1035-43.
52 Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Epigenetic regulation of ASC/TMS1 expression: potential role in apoptosis and inflammasome function. Cell Mol Life Sci 2014:71(10):1855-64.
53 Salminen A, Kauppinen A, Hiltunen M, Kaarniranta K. Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. Ageing Res Rev 2014(16):45-65.
54 Salminen A, Kauppinen A, Kaarniranta K. Inflammaging signaling in healths pan and life span regulation: Next generation targets for longevity. In: Rahman I, Bagchi D, eds. Inflammation, advancing age and nutrition: research and clinical interventions, p. 323-332. Amsterdam: Academic Press, 2014.
55 Sattlecker M, Kiddle SJ, Newhouse S, ..., Soininen H, Kloszewska I, Mecocci P, Tsolaki M, Vellas B, Lovestone S; the Addneuromed Consortium, Dobson RJ. Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology. Alzheimers Dement 2014:10(6):724-34.
56 Seppälä TT, Louhija UM, Appelberg B, Herukka SK, Juva K. Comparison Between Clinical Diagnosis and CSF Biomarkers of Alzheimer Disease in Elderly Patients with Late Onset Psychosis: Helsinki Old Age Psychosis Study (HOPS). Am J Geriatr Psychiatry 2014:22(9):908-16.
57 Simonsen AH1, Mattila J, Hejl AM, Garde E, van Gils M, Thomsen C, Lötjönen J, Soininen H, Waldemar G. Application of the PredictAD decision support tool to a Danish cohort of patients with Alzheimer's disease and other dementias. Dement Geriatr Cogn Disord 2014:37(3-4):207-13.
58 Simula S, Muuronen AT, Taina M, Jäkälä P, Sipola P, Vanninen R, Hedman M. Effect of middle cerebral artery territory ischemic stroke on QT interval. J Stroke Cerebrovasc Dis 2014:23(4):717-23.
59 Sutinen EM1, Korolainen MA2, Häyrinen J3, Alafuzoff I4, Petratos S5, Salminen A6, Soininen H7, Pirttilä T7, Ojala JO1. Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells. Front Cell Neurosci 2014:7(8):214.
60 Taina M, Sipola P, Muuronen A, Hedman M, Mustonen P, Kantanen AM, Jäkälä P, Vanninen R. Determinants of Left Atrial Appendage Volume in Stroke Patients without Chronic Atrial Fibrillation . PLoS ONE 2014:9(3):e90903.
61 Taina M1, Korhonen M1, Haataja M1, Muuronen A1, Arponen O1, Hedman M2, Jäkälä P3, Sipola P1, Mustonen P4, Vanninen R. Morphological and volumetric analysis of left atrial appendage and left atrium: cardiac computed tomography-based reproducibility assessment. PLoS ONE 2014:9(7):e101580.
62 Takalo M1, Haapasalo A1, Martiskainen H1, Kurkinen KM1, Koivisto H2, Miettinen P2, Khandelwal VK2, Kemppainen S2, Kaminska D3, Mäkinen P1, Leinonen V, Pihlajamäki J, Soininen H, Laakso M, Tanila H, Hiltunen M9. High-fat diet increases tau expression in the brain of T2DM and AD mice independently of peripheral metabolic status. J Nutr Biochem 2014:25(6):634-41.
63 Tolppanen AM, Ngandu T, Kåreholt I, Laatikainen T, Rusanen M, Soininen H, Kivipelto M. Midlife and late-life body mass index and late-life dementia: results from a prospective population-based cohort . J Alzheimer Dis 2014:38(1):201-9.
64 Vuorinen M1, Damangir S2, Niskanen E3, Miralbell J4, Rusanen M1, Spulber G2, Soininen H1, Kivipelto M5, Solomon A5. Coronary heart disease and cortical thickness, gray matter and white matter lesion volumes on MRI. PLoS ONE 2014:9(10):e109250.
65 Välimäki T1, Martikainen J2, Hongisto K3, Fraunberg M, Hallikainen I3, Sivenius J3, Vehviläinen-Julkunen K1, Pietilä AM, Koivisto AM3. Decreasing sense of coherence and its determinants in spousal caregivers of persons with mild Alzheimer's disease in three year follow-up: ALSOVA study. Int Psychogeriatr 2014:26(7):1211-20.
66 Whiley L, Sen A, Heaton J, ..., Soininen H, ..., Legido-Quigley C. Evidence of altered phosphatidylcholine metabolism in Alzheimer's disease. Neurobiol Aging 2014:35(2):271-278.
67 Yang H1, Lyutvinskiy Y1, Herukka SK2, Soininen H2, Rutishauser D1, Zubarev RA3. Prognostic polypeptide blood plasma biomarkers of Alzheimer's disease progression. J Alzheimer Dis 2014:40(3):659-66.

Neurologian yksikkö Department of Neurology
Julkaisutietokanta 5.12.2019 Publications Data Base 5.12.2019